4-CHLOROBENZANILIDE

Base Information

• Chemical Name: 4-CHLOROBENZANILIDE
• CAS No.: 6833-15-4
• Molecular Formula: C13H10ClNO
• Molecular Weight: 231.681
• Hs Code.: 2924299090
• Mol file: 6833-15-4.mol

Synonyms:Benzanilide,4-chloro- (6CI,7CI,8CI);4-Chloro-N-phenylbenzamide;4-Chlorobenzanilide;N-Phenyl-4-chlorobenzamide;N-Phenyl-p-chlorobenzamide;NSC 404952;p-Chlorobenzanilide;

Chemical Property of 4-CHLOROBENZANILIDE

Chemical Property:

• Appearance/Colour: white to grey crystalline powder
• Vapor Pressure: 0.00232mmHg at 25°C
• Melting Point: 199-201 °C(lit.)
• Refractive Index: 1.649
• Boiling Point: 288.6 °C at 760 mmHg
• Flash Point: 128.3 °C
• PSA: 29.10000
• Density: 1.285 g/cm³
• LogP: 3.66530
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4-Chlorobenzanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-CHLOROBENZANILIDE

There total 155 articles about 4-CHLOROBENZANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

aniline (62-53-3) + para-Chlorobenzyl alcohol (873-76-7) → 4-chlorobenzanilide (6833-15-4)

Guidance literature:

With oxygen; lithium hydroxide; In water; at 50 ℃; for 12h;

DOI:10.1002/anie.201102374

Reference yield: 94.0%

4-cholorobenzophenone oxime (2998-98-3,2998-99-4,38032-14-3) → 4-chlorobenzanilide (6833-15-4)

Guidance literature:

With thionyl chloride; β‐cyclodextrin; In water; acetone; at 80 ℃; for 0.3h;

DOI:10.1080/00397911.2011.592747

Reference yield: 89.0%

4-chlorobenzenecarbothioic acid (31143-03-0) + aniline (62-53-3) → 4-chlorobenzanilide (6833-15-4)

Guidance literature:

With air; In ethyl acetate; at 20 ℃; for 24h;

DOI:10.1002/cssc.201900814

upstream raw materials:

(Z)-(4-chlorophenyl)(phenyl)methanone oxime

4-chlorobenzaldehyde

phenyl isocyanate

chlorobenzene

Downstream raw materials:

4-chloro-4'-(N-methyl-anilino)-benzophenone

4-chloro-N-phenyl-benzimidoyl chloride

N,N'-diphenyl-4-chlorobenzamidine

6-chloro-1'-methyl-spiro[isobenzofuran-1,4'-piperidin]-3-one

Refernces

• 1、 Zhao, Rong,Dong, Wenwen,Teng, Jiangge,Wang, Zhiwei,Wang, Yunzhong,Yang, Jianguo,Jia, Qiang,Chu, Changhu. "Activated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides". supporting information. . Retrieved 2020/12/21.
• 2、 Li, Min-Xin,Li, Mei-Ling,Tang, Yan-Ling,Sun, Yun,Qu, Lu,Huang, Feng,Mao, Ze-Wei. "Exploration of Cu-catalyzed regioselective hydrodehalogenation of o-haloanilides using EtOH as hydrogen source". supporting information. . Retrieved 2021/05/03.