Bafilomycin C1

Base Information

• Chemical Name: Bafilomycin C1
• CAS No.: 88979-61-7
• Molecular Formula: C39H60 O12
• Molecular Weight: 720.8865
• Wikidata: Q105312966
• Mol file: 88979-61-7.mol

Synonyms:bafilomycin C1;bafilomycin-C1

Chemical Property of Bafilomycin C1

Chemical Property:

• Appearance/Colour: Light tan solid
• Vapor Pressure: 3.79E-33mmHg at 25°C
• Boiling Point: 844.4 °C at 760 mmHg
• Flash Point: 248.9 °C
• PSA: 178.28000
• Density: 1.18 g/cm³
• LogP: 4.88440
• XLogP3: 6.4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 11
• Exact Mass: 720.40847734
• Heavy Atom Count: 51
• Complexity: 1350

Purity/Quality:

98%Min ^*data from raw suppliers

Bafilomycin C1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)O)O)O)OC)C
• Isomeric SMILES: C[C@H]1C/C(=C/C=C\[C@@H](C(OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)OC(=O)/C=C/C(=O)O)O)O)OC)/C
• Uses: Bafilomycin C1 is a member of a potent family of macrocyclic lactones. Bafilomycin C1 shares a similar mode of action and activity as its more accessible A1 analogue. Bafilomycin C1 is broadly active against bacteria, fungi, insects, nematodes and cestodes. Bafilomycin C1 has attracted interest as a potential agent for treating osteoporosis. The presence of the fumarate group provides an ideal ligand for affinity chromatography of V-ATPase. Bafilomycin C1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases). It blocks these pumps in mammalian, plant, or fungal cells, preventing proton transport and compartment acidification. Bafilomycin C1 has been shown to have angiostatic activity in the chick chorioallantoic membrane assay. It has also been used, when coupled to cellulose, to purify V-ATPases.[Cayman Chemical]