5'-O-dimethoxytrityl-O(4)-4-nitrophenylethyl-2'-O-4-nitrophenylethylsulfonyluridine

Base Information

Chemical Name:5'-O-dimethoxytrityl-O(4)-4-nitrophenylethyl-2'-O-4-nitrophenylethylsulfonyluridine
CAS No.:114522-13-3
Molecular Formula:C₄₆H₄₄N₄O₁₄S
Molecular Weight:908.94
Hs Code.:
Mol file:114522-13-3.mol

Synonyms:5’-O-dimethoxytrityl-O(4)-4-nitrophenylethyl-2’-O-4-nitrophenylethylsulfonyluridine

Suppliers and Price of 5'-O-dimethoxytrityl-O(4)-4-nitrophenylethyl-2'-O-4-nitrophenylethylsulfonyluridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 5'-O-dimethoxytrityl-O(4)-4-nitrophenylethyl-2'-O-4-nitrophenylethylsulfonyluridine

Chemical Property:

Boiling Point:1033.3°Cat760mmHg
PKA:12.71±0.70(Predicted)
Flash Point:578.7°C
Density:1.38g/cm³

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 5'-O-dimethoxytrityl-O(4)-4-nitrophenylethyl-2'-O-4-nitrophenylethylsulfonyluridine

There total 11 articles about 5'-O-dimethoxytrityl-O(4)-4-nitrophenylethyl-2'-O-4-nitrophenylethylsulfonyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 80259-15-0
2-(4-nitro-phenyl)ethanesulfonyl chloride

: 114522-12-2
5'-O-(dimethoxytrityl)-O⁴-<2-(4-nitrophenyl)ethyl>uridine

: 114522-13-3
5'-O-(dimethoxytrityl)-O⁴-<2-(4-nitrophenyl)ethyl>-3'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

: 5'-O-(dimethoxytrityl)-O⁴-<2-(4-nitrophenyl)ethyl>-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

: 5'-O-(dimethoxytrityl)-O⁴-<2-(4-nitrophenyl)ethyl>-2',3'-bis-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

Guidance literature:: With triethylamine; In dichloromethane; at -10 ℃; for 0.416667h;
DOI:10.1002/hlca.19950780706

Reference yield: 20.0%

: 80259-15-0
2-(4-nitro-phenyl)ethanesulfonyl chloride

: 114522-12-2
5'-O-(dimethoxytrityl)-O⁴-<2-(4-nitrophenyl)ethyl>uridine

: 114522-13-3
5'-O-(dimethoxytrityl)-O⁴-<2-(4-nitrophenyl)ethyl>-3'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

: 5'-O-(dimethoxytrityl)-O⁴-<2-(4-nitrophenyl)ethyl>-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

Guidance literature:: With di(n-butyl)tin oxide; tetrahexylammonium chloride; In acetonitrile; for 24h; Ambient temperature;
DOI:10.1002/hlca.19950780706

Reference yield:

: 4105-38-8
Tri-O-acetyluridine

: 114522-13-3
5'-O-(dimethoxytrityl)-O⁴-<2-(4-nitrophenyl)ethyl>-3'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) POCl₃, Et₃N / 1.) MeCN, 60 min, 0 deg C, 2.) MeCN, 16 h, RT

2: 23 percent / Et₃N / toluene / 66 h / Heating

3: 79 percent / pyridine / 20 h / Ambient temperature

4: 42 percent / dibutyltin oxide, tetrahexylammonium chloride / acetonitrile / 24 h / Ambient temperature

With pyridine; di(n-butyl)tin oxide; tetrahexylammonium chloride; triethylamine; trichlorophosphate; In toluene; acetonitrile;
DOI:10.1002/hlca.19950780706