2-(p-Chlorophenyl)-4-methyl-5-thiazoleacetic acid

Base Information

Chemical Name:2-(p-Chlorophenyl)-4-methyl-5-thiazoleacetic acid
CAS No.:17969-41-4
Molecular Formula:C12H10ClNO2S
Molecular Weight:267.736
Hs Code.:2934100090
DSSTox Substance ID:DTXSID00170853
Nikkaji Number:J59.588H
Wikidata:Q83040870
Mol file:17969-41-4.mol

Synonyms:2-(p-Chlorophenyl)-4-methyl-5-thiazoleacetic acid;17969-41-4;BRN 1122113;5-THIAZOLEACETIC ACID, 2-(p-CHLOROPHENYL)-4-METHYL-;2-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]acetic acid;Acide p-chlorophenyl-2 methyl-4-thiazole-acetique-5;Acide p-chlorophenyl-2 methyl-4-thiazole-acetique-5 [French];SCHEMBL2069982;DTXSID00170853;AKOS013989954;LS-150717;2-(4'-Chlorophenyl)-4-methylthiazole-5-acetic acid;2-Thiazoleacetic acid, 2-(4-chlorophenyl)-4-methyl-;2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]acetic acid;[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]acetic acid #

Suppliers and Price of 2-(p-Chlorophenyl)-4-methyl-5-thiazoleacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-(p-Chlorophenyl)-4-methyl-5-thiazoleacetic acid

Chemical Property:

Vapor Pressure:3.94E-09mmHg at 25°C
Boiling Point:456.6°C at 760 mmHg
Flash Point:230°C
PSA：78.43000
Density:1.386g/cm³
LogP:3.39900
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:267.0120774
Heavy Atom Count:17
Complexity:282

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(SC(=N1)C2=CC=C(C=C2)Cl)CC(=O)O

Technology Process of 2-(p-Chlorophenyl)-4-methyl-5-thiazoleacetic acid

There total 1 articles about 2-(p-Chlorophenyl)-4-methyl-5-thiazoleacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17969-41-4
[2-(4-chloro-phenyl)-4-methyl-thiazol-5-yl]-acetic acid

Guidance literature:

Reference yield: 84.0%

: 17969-41-4
[2-(4-chloro-phenyl)-4-methyl-thiazol-5-yl]-acetic acid

: 27473-06-9
2-[2-(4-chloro-phenyl)-4-methyl-thiazol-5-yl]-ethanol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

: 17969-41-4
[2-(4-chloro-phenyl)-4-methyl-thiazol-5-yl]-acetic acid

: 876147-68-1
N-(piperidin-3-yl)-2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl] acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

2: hydrogenchloride / methanol

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.11.002