Methyl 2-(5-methyl-2-benzofuranyl)benzoate

Base Information

Chemical Name:Methyl 2-(5-methyl-2-benzofuranyl)benzoate
CAS No.:143381-73-1
Molecular Formula:C17H14O3
Molecular Weight:266.296
Hs Code.:
DSSTox Substance ID:DTXSID401268271
Mol file:143381-73-1.mol

Synonyms:Methyl 2-(5-methyl-2-benzofuranyl)benzoate;SCHEMBL7309294;RSIAMUSQIKRMSE-UHFFFAOYSA-N;DTXSID401268271;143381-73-1

Suppliers and Price of Methyl 2-(5-methyl-2-benzofuranyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-(5-methyl-2-benzofuranyl)benzoate

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:266.094294304
Heavy Atom Count:20
Complexity:354

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC2=C(C=C1)OC(=C2)C3=CC=CC=C3C(=O)OC

Technology Process of Methyl 2-(5-methyl-2-benzofuranyl)benzoate

There total 1 articles about Methyl 2-(5-methyl-2-benzofuranyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 18441-43-5
5-methylbenzofuran

: 342-54-1
2-(methoxycarbonyl)benzenediazonium tetrafluoroborate

: 143381-73-1
methyl 2-(5-methyl-2-benzofuranyl)benzoate

Guidance literature:: With palladium diacetate; trifluoroacetic acid; In methanol; at 20 ℃;
DOI:10.1039/c6sc02595a

Reference yield: 100.0%

: 143381-73-1
methyl 2-(5-methyl-2-benzofuranyl)benzoate

: 143381-74-2
methyl 2-(3-bromo-5-methyl-2-benzofuranyl)benzoate

Guidance literature:: With bromine; In tetrachloromethane; at 0 - 5 ℃; for 0.666667h;
DOI:10.1021/jm00045a016

Reference yield:

: 143381-73-1
methyl 2-(5-methyl-2-benzofuranyl)benzoate

: 146624-63-7
3-[2-(2-Amino-phenyl)-3-ethyl-benzofuran-5-ylmethyl]-5-cyclopropyl-2-ethyl-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / Br₂ / CCl₄ / 0.67 h / 0 - 5 °C

2: 92 percent / aq. NaOH / methanol / 3 h / Heating

3: 18 percent / diphenylphosphorazidate, Et₃N / dioxane / 20 h / Heating

4: 97 percent / NBS, benzoyl peroxide / CCl₄ / 1.5 h / Heating; Irradiation

5: 62 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

6: 32 percent / bis(triphenylphosphine)palladium dichloride, CuI, diethylamine / 29 h / 90 °C

7: 72 percent / aq. NaOH / methanol; tetrahydrofuran / 16 h / Ambient temperature

8: 88 percent / H₂ / 10percent Pd/C / ethanol / 0.33 h / 760 Torr / Ambient temperature

9: trifluoroacetic acid / CH₂Cl₂ / 16 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-Bromosuccinimide; copper(l) iodide; Perbenzoic acid; diphenyl phosphoryl azide; hydrogen; bromine; potassium carbonate; diethylamine; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016