L-Histidinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[1-(cyclohexylmethyl)- 2-hydroxy-3-[[2-[(1-oxido-1-azabicyclo[2.2.2]oct-3-yl)amino]-2-oxoethyl] sulfonyl]propyl]-

Base Information

Chemical Name:L-Histidinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[1-(cyclohexylmethyl)- 2-hydroxy-3-[[2-[(1-oxido-1-azabicyclo[2.2.2]oct-3-yl)amino]-2-oxoethyl] sulfonyl]propyl]-
CAS No.:143396-51-4
Molecular Formula:C39H59N7O9S
Molecular Weight:802.005
Hs Code.:
Mol file:143396-51-4.mol

L-Histidinamide,
N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[1-(cyclohexylmethyl)-
2-hydroxy-3-[[2-[(1-oxido-1-azabicyclo[2.2.2]oct-3-yl)amino]-2-oxoethyl]
sulfonyl]propyl]-

Synonyms:

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Chemical Property of L-Histidinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[1-(cyclohexylmethyl)- 2-hydroxy-3-[[2-[(1-oxido-1-azabicyclo[2.2.2]oct-3-yl)amino]-2-oxoethyl] sulfonyl]propyl]-

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Technology Process of L-Histidinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[1-(cyclohexylmethyl)- 2-hydroxy-3-[[2-[(1-oxido-1-azabicyclo[2.2.2]oct-3-yl)amino]-2-oxoethyl] sulfonyl]propyl]-

There total 7 articles about L-Histidinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[1-(cyclohexylmethyl)- 2-hydroxy-3-[[2-[(1-oxido-1-azabicyclo[2.2.2]oct-3-yl)amino]-2-oxoethyl] sulfonyl]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 142843-22-9
4-((S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-{(1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-[(1-oxy-1-aza-bicyclo[2.2.2]oct-3-ylcarbamoyl)-methanesulfonyl]-propylcarbamoyl}-ethyl)-imidazole-1-carboxylic acid tert-butyl ester

: 143396-51-4
{(S)-1-[(S)-1-{(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-[(1-oxy-1-aza-bicyclo[2.2.2]oct-3-ylcarbamoyl)-methanesulfonyl]-propylcarbamoyl}-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With ammonia; In methanol; for 3h; Ambient temperature;
DOI:10.1021/jm00093a009

Reference yield:

: 76883-48-2,120570-05-0,123536-15-2,6238-14-8,781591-76-2
quinuclidin-3-amine

: 143396-51-4
{(S)-1-[(S)-1-{(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-[(1-oxy-1-aza-bicyclo[2.2.2]oct-3-ylcarbamoyl)-methanesulfonyl]-propylcarbamoyl}-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / ethanol / 3 h / 90 °C

2: ethanolic HCl / 1 h / Ambient temperature

3: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

4: 40 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 24 percent / NH₃ (gas) / methanol / 3 h / Ambient temperature

With hydrogenchloride; ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00093a009

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 143396-51-4
{(S)-1-[(S)-1-{(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-[(1-oxy-1-aza-bicyclo[2.2.2]oct-3-ylcarbamoyl)-methanesulfonyl]-propylcarbamoyl}-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / triethylamine / ethanol

2: 75 percent / ethanol / 3 h / 90 °C

3: ethanolic HCl / 1 h / Ambient temperature

4: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

5: 40 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

6: 24 percent / NH₃ (gas) / methanol / 3 h / Ambient temperature

With hydrogenchloride; ammonia; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00093a009