Benzenepropanoic acid, 4-(1H-imidazol-1-yl)-, ethyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, 4-(1H-imidazol-1-yl)-, ethyl ester
• CAS No.: 143426-74-8
• Molecular Formula: C14H16N2O2
• Molecular Weight: 244.293
• Mol file: 143426-74-8.mol

Synonyms:

Chemical Property of Benzenepropanoic acid, 4-(1H-imidazol-1-yl)-, ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanoic acid, 4-(1H-imidazol-1-yl)-, ethyl ester

There total 5 articles about Benzenepropanoic acid, 4-(1H-imidazol-1-yl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-3-(4-Imidazol-1-yl-phenyl)-acrylic acid ethyl ester (74002-94-1) → 3-(4-Imidazol-1-yl-phenyl)-propionic acid ethyl ester (143426-74-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 45 ℃; for 4h; under 3040 Torr;

DOI:10.1016/0223-5234(92)90005-L

Reference yield:

4-fluorobenzoic acid ethyl ester (451-46-7) → 3-(4-Imidazol-1-yl-phenyl)-propionic acid ethyl ester (143426-74-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 51 percent / NaH / dimethylsulfoxide / 18 h / 100 °C

2: 57 percent / NaBH₄, CaCl₂ / tetrahydrofuran / Ambient temperature

3: 51 percent / pyridinium chlorochromate (PCC) / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 93 percent / K₂CO₃ / ethanol / 2 h / 70 °C

5: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 45 °C / 3040 Torr

With sodium tetrahydroborate; hydrogen; sodium hydride; potassium carbonate; pyridinium chlorochromate; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/0223-5234(92)90005-L

Reference yield:

ethyl 4-(imidazol-1-yl)benzoate (86718-07-2) → 3-(4-Imidazol-1-yl-phenyl)-propionic acid ethyl ester (143426-74-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / NaBH₄, CaCl₂ / tetrahydrofuran / Ambient temperature

2: 51 percent / pyridinium chlorochromate (PCC) / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 93 percent / K₂CO₃ / ethanol / 2 h / 70 °C

4: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 45 °C / 3040 Torr

With sodium tetrahydroborate; hydrogen; potassium carbonate; pyridinium chlorochromate; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;

DOI:10.1016/0223-5234(92)90005-L

upstream raw materials:

(E)-3-(4-Imidazol-1-yl-phenyl)-acrylic acid ethyl ester

4-fluorobenzoic acid ethyl ester

ethyl 4-(imidazol-1-yl)benzoate

1-(4-formylphenyl)-1H-imidazole

Downstream raw materials:

3-(4-Imidazol-1-yl-phenyl)-propionic acid hydrazide