IOFETAMINE HCL

Base Information

• Chemical Name: IOFETAMINE HCL
• CAS No.: 95896-48-3
• Molecular Formula: C₁₂H₁₈IN
• Molecular Weight: 303.186
• Mol file: 95896-48-3.mol

Synonyms:N-Isopropyl-p-iodoamphetamine;4-IODO-N-ISOPROPYLAMPHETAMINE HYDROCHLORIDE;1-(4-iodophenyl)-N-propan-2-ylpropan-2-amine;IOFETAMINE HCL;1-(4-Iodophenyl)-2-isopropylamino propane;4-IODO-N-ISOPROPYLAMPHETAMINE;Iofetamine hydrochloride;(±)-N-Isopropyl-4-iodoamphetamine;

Chemical Property of IOFETAMINE HCL

Chemical Property:

• Boiling Point: 307.6°Cat760mmHg
• Flash Point: 139.8°C
• PSA: 12.03000
• Density: 1.378g/cm³
• LogP: 3.61110

Purity/Quality:

95% ^*data from raw suppliers

Iofetamine hydrochloride analytical standard, for drug analysis ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of IOFETAMINE HCL

There total 10 articles about IOFETAMINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(4-(2-(2-propylamino)propyl)benzeneazo)piperidine (123012-96-4) → N-isopropyl-para-iodoamphetamine (82691-33-6,95896-48-3)

Guidance literature:

With sodium iodide; In acetone; trifluoroacetic acid; 1.) addition at 0-5 deg C, 2.) R_.T_. 20 min.;

Reference yield:

N-isopropyl-2-amino-1-phenylpropane (33236-69-0) → N-isopropyl-para-iodoamphetamine (82691-33-6,95896-48-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 96 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 1.) 15 min, R_.T_., 2.) reflux, 1 h.

2: 1.) thallium(III) trifluoroacetate, 2.) amyl nitrite / 1.) trifluoroacetic acid, in the dark 75 h at R_.T_., 2.) dichloromethane, in the dark 3 h.

3: 93 percent / sodium borohydride / 10percent Pd/C / methanol / 1 h / Ambient temperature

4: 1.) 1M HCl, sodium nitrite / 1.) ethanol, water, 0-5 deg C, 10 min, 2.) 30 min.

5: 73 percent / 10percent potassium hydroxide / ethanol / 16 h / Heating; in the dark

6: 80 percent / sodium iodide / acetone; trifluoroacetic acid / 1.) addition at 0-5 deg C, 2.) R_.T_. 20 min.

With hydrogenchloride; dmap; potassium hydroxide; sodium tetrahydroborate; n-Amyl nitrite; sodium iodide; sodium nitrite; thallium(III) trifluoroacetate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetone; trifluoroacetic acid;

Reference yield:

amphetamine sulfate (62306-10-9) → N-isopropyl-para-iodoamphetamine (82691-33-6,95896-48-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / sodium borohydride / methanol / 14 h / Ambient temperature

2: 96 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 1.) 15 min, R_.T_., 2.) reflux, 1 h.

3: 1.) thallium(III) trifluoroacetate, 2.) amyl nitrite / 1.) trifluoroacetic acid, in the dark 75 h at R_.T_., 2.) dichloromethane, in the dark 3 h.

4: 93 percent / sodium borohydride / 10percent Pd/C / methanol / 1 h / Ambient temperature

5: 1.) 1M HCl, sodium nitrite / 1.) ethanol, water, 0-5 deg C, 10 min, 2.) 30 min.

6: 73 percent / 10percent potassium hydroxide / ethanol / 16 h / Heating; in the dark

7: 80 percent / sodium iodide / acetone; trifluoroacetic acid / 1.) addition at 0-5 deg C, 2.) R_.T_. 20 min.

With hydrogenchloride; dmap; potassium hydroxide; sodium tetrahydroborate; n-Amyl nitrite; sodium iodide; sodium nitrite; thallium(III) trifluoroacetate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetone; trifluoroacetic acid;

upstream raw materials:

1-(4-(2-(2-propylamino)propyl)benzeneazo)piperidine

N-isopropyl-2-amino-1-phenylpropane

amphetamine sulfate

N-trifluoroacetyl-N-isopropyl-2-amino-1-(4-aminophenyl)propane