4-[4-(Morpholinomethyl)phenylsulfonyl]thiophene-2-sulfonamide

Base Information

Chemical Name:4-[4-(Morpholinomethyl)phenylsulfonyl]thiophene-2-sulfonamide
CAS No.:143509-51-7
Molecular Formula:C₁₅H₁₈N₂O₅S₃
Molecular Weight:402.516
Hs Code.:
DSSTox Substance ID:DTXSID30877828
Nikkaji Number:J516.924K
Wikidata:Q82859715
ChEMBL ID:CHEMBL1195683
Mol file:143509-51-7.mol

Synonyms:CHEMBL555153;143509-51-7;CHEMBL1195683;DTXSID30877828;BDBM50003252;THIOPHENE2SULFONAMIDE44MORPHOLIN1YLMETHYLPHENYLS;4-[4-(Morpholinomethyl)phenylsulfonyl]thiophene-2-sulfonamide;4-(4-Morpholin-4-ylmethyl-benzenesulfonyl)-thiophene-2-sulfonic acid amide;hydrochloride

Suppliers and Price of 4-[4-(Morpholinomethyl)phenylsulfonyl]thiophene-2-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[4-(Morpholinomethyl)phenylsulfonyl]thiophene-2-sulfonamide

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:402.03778520
Heavy Atom Count:25
Complexity:642

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1CC2=CC=C(C=C2)S(=O)(=O)C3=CSC(=C3)S(=O)(=O)N

Technology Process of 4-[4-(Morpholinomethyl)phenylsulfonyl]thiophene-2-sulfonamide

There total 6 articles about 4-[4-(Morpholinomethyl)phenylsulfonyl]thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62141-76-8
3-<(4-methylphenyl)sulfonyl>thiophene

: 143509-51-7
4-<<4-(morpholinomethyl)phenyl>sulfonyl>thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid, PCl₅ / 0.42 h / 55 °C

2: N-bromosuccinimide, benzoyl peroxide / CHCl₃ / 1 h / Heating; Irradiation

3: 57 percent / NH₃ (gas) / CHCl₃ / 3 h / Ambient temperature

4: tetrahydrofuran / 48 h / Ambient temperature

With chlorosulfonic acid; N-Bromosuccinimide; Perbenzoic acid; phosphorus pentachloride; ammonia; In tetrahydrofuran; chloroform;
DOI:10.1021/jm00099a010

Reference yield:

: 42057-02-3
3-<(4-methylphenyl)thio>thiophene

: 143509-51-7
4-<<4-(morpholinomethyl)phenyl>sulfonyl>thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / m-chloroperbenzoic acid (MCPBA) / CHCl₃ / 1.5 h / 0 - 10 °C

2: chlorosulfonic acid, PCl₅ / 0.42 h / 55 °C

3: N-bromosuccinimide, benzoyl peroxide / CHCl₃ / 1 h / Heating; Irradiation

4: 57 percent / NH₃ (gas) / CHCl₃ / 3 h / Ambient temperature

5: tetrahydrofuran / 48 h / Ambient temperature

With chlorosulfonic acid; N-Bromosuccinimide; Perbenzoic acid; phosphorus pentachloride; ammonia; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform;
DOI:10.1021/jm00099a010

Reference yield:

: 103-19-5
di(p-tolyl) disulfide

: 143509-51-7
4-<<4-(morpholinomethyl)phenyl>sulfonyl>thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-butyllithium / 1.) ether, hexane, -78 deg C, 45 min, 2.) ether, hexane, from -78 deg C to RT, overnight

2: 78 percent / m-chloroperbenzoic acid (MCPBA) / CHCl₃ / 1.5 h / 0 - 10 °C

3: chlorosulfonic acid, PCl₅ / 0.42 h / 55 °C

4: N-bromosuccinimide, benzoyl peroxide / CHCl₃ / 1 h / Heating; Irradiation

5: 57 percent / NH₃ (gas) / CHCl₃ / 3 h / Ambient temperature

6: tetrahydrofuran / 48 h / Ambient temperature

With chlorosulfonic acid; N-Bromosuccinimide; n-butyllithium; Perbenzoic acid; phosphorus pentachloride; ammonia; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; chloroform;
DOI:10.1021/jm00099a010