methyl (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenyl-butyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-pentanoyl]amino]-3-phenyl-propanoate

Base Information

Chemical Name:methyl (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenyl-butyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-pentanoyl]amino]-3-phenyl-propanoate
CAS No.:215511-56-1
Molecular Formula:C40H54N4O7
Molecular Weight:702.8794
Hs Code.:
Mol file:215511-56-1.mol

methyl (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenyl-butyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-pentanoyl]amino]-3-phenyl-propanoate

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenyl-butyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-pentanoyl]amino]-3-phenyl-propanoate

Chemical Property:

Vapor Pressure:5.94E-34mmHg at 25°C
Boiling Point:889.5°Cat760mmHg
Flash Point:491.7°C
Density:1.152g/cm³

Purity/Quality:

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Technology Process of methyl (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenyl-butyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-pentanoyl]amino]-3-phenyl-propanoate

There total 8 articles about methyl (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-4-phenyl-butyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-pentanoyl]amino]-3-phenyl-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-{(2R,3R)-2-[(R)-2-((S)-3-tert-Butoxycarbonylamino-2-oxo-4-phenyl-butylamino)-3-phenyl-propionylamino]-3-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester

: 215511-56-1
(R)-2-{(2R,3R)-2-[(R)-2-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-3-phenyl-propionylamino]-3-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/S0223-5234(98)80043-3

Reference yield:

: (S)-2-{(2S,3S)-2-[(S)-2-((S)-3-tert-Butoxycarbonylamino-2-oxo-4-phenyl-butylamino)-3-phenyl-propionylamino]-3-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester

: 215511-56-1
(S)-2-{(2S,3S)-2-[(S)-2-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-3-phenyl-propionylamino]-3-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/S0223-5234(98)80043-3

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 215511-56-1
(R)-2-{(2R,3R)-2-[(R)-2-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-3-phenyl-propionylamino]-3-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NMM, iBuOCOCl / 1) DME, -15 deg C, 2) DME, ether, 0 deg C, 2 h

2: HCl / diethyl ether / 0 °C

3: NaHCO₃, NaI / dimethylformamide

4: NaBH₄ / dimethylformamide / 0 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; sodium hydrogencarbonate; sodium iodide; isobutyl chloroformate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(98)80043-3