1,3,5-Triazin-2(1H)-one, tetrahydro-1,3-bis(phenylmethyl)-5-[3-[[4-[tetrahydro-4-oxo-3,5-bis(phen ylmethyl)-1,3,5-triazin-1(2H)-yl]butyl]amino]propyl]-

Base Information

• Chemical Name: 1,3,5-Triazin-2(1H)-one, tetrahydro-1,3-bis(phenylmethyl)-5-[3-[[4-[tetrahydro-4-oxo-3,5-bis(phen ylmethyl)-1,3,5-triazin-1(2H)-yl]butyl]amino]propyl]-
• CAS No.: 143565-69-9
• Molecular Formula: C41H51N7O2
• Molecular Weight: 673.902
• Mol file: 143565-69-9.mol

Synonyms:

Chemical Property of 1,3,5-Triazin-2(1H)-one, tetrahydro-1,3-bis(phenylmethyl)-5-[3-[[4-[tetrahydro-4-oxo-3,5-bis(phen ylmethyl)-1,3,5-triazin-1(2H)-yl]butyl]amino]propyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,5-Triazin-2(1H)-one, tetrahydro-1,3-bis(phenylmethyl)-5-[3-[[4-[tetrahydro-4-oxo-3,5-bis(phen ylmethyl)-1,3,5-triazin-1(2H)-yl]butyl]amino]propyl]-

There total 12 articles about 1,3,5-Triazin-2(1H)-one, tetrahydro-1,3-bis(phenylmethyl)-5-[3-[[4-[tetrahydro-4-oxo-3,5-bis(phen ylmethyl)-1,3,5-triazin-1(2H)-yl]butyl]amino]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C41H49N7O2 (1028256-98-5) → 4-aza-1,3-bis(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)octane (143565-69-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 23 ℃; for 20h; Yield given;

DOI:10.1021/jo00049a036

Reference yield:

1,3-dibenzylurea (1466-67-7) → 4-aza-1,3-bis(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)octane (143565-69-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) i-Pr₂NEt / 1) H₂O, 10 min, 2) EtOAc, reflux

2: 80 percent / LiBH₄ / tetrahydrofuran / Heating

3: i-Pr₂NEt / CH₂Cl₂ / 0.17 h / 0 °C

4: NaN₃ / dimethylformamide / 1.25 h / 80 °C

5: 1) PPh₃, molecular sieves 4 Angstroem / 1) THF, 23 deg C, 45 min, 2) THF, 30 min

6: NaBH₄ / ethanol / 20 h / 23 °C

With sodium tetrahydroborate; lithium borohydride; sodium azide; 4 A molecular sieve; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00049a036

Reference yield:

benzyl isothiocyanate (3173-56-6) → 4-aza-1,3-bis(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)octane (143565-69-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 99 percent / CH₂Cl₂ / 0.5 h / 5 °C

2: 1) i-Pr₂NEt / 1) H₂O, 10 min, 2) EtOAc, reflux

3: 80 percent / LiBH₄ / tetrahydrofuran / Heating

4: i-Pr₂NEt / CH₂Cl₂ / 0.17 h / 0 °C

5: NaN₃ / dimethylformamide / 1.25 h / 80 °C

6: 1) PPh₃, molecular sieves 4 Angstroem / 1) THF, 23 deg C, 45 min, 2) THF, 30 min

7: NaBH₄ / ethanol / 20 h / 23 °C

With sodium tetrahydroborate; lithium borohydride; sodium azide; 4 A molecular sieve; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00049a036

upstream raw materials:

C₄₁H₄₉N₇O₂

1,3-dibenzylurea

4-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)butyraldehyde

5-(4-hydroxybutyl)-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine

Downstream raw materials:

N-(3-aminopropyl)-1,4-diaminobutane

Refernces