Chemical Property of 2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-
Chemical Property:
- Vapor Pressure:0.65mmHg at 25°C
- Boiling Point:668.6°Cat760mmHg
- PKA:12.50±0.40(Predicted)
- Flash Point:358.2°C
- PSA：130.33000
- Density:1.622g/cm3
- LogP:-2.73000
- Storage Temp.:-20°C
- Solubility.:Methanol (Slightly), Water (Slightly)
- XLogP3:-2.4
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:248.10083623
- Heavy Atom Count:17
- Complexity:301
- Purity/Quality:
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99% *data from raw suppliers
3,4,5,6-Tetrahydrouridine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CN(C(=O)NC1O)C2C(C(C(O2)CO)O)O
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Description
Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively).Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome. Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively). Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2’-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.
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Uses
3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
