Pyridine, 4-[5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]-

Base Information

Chemical Name:Pyridine, 4-[5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]-
CAS No.:143703-84-8
Molecular Formula:C14H8F3N3O
Molecular Weight:291.232
Hs Code.:
DSSTox Substance ID:DTXSID30357337
Nikkaji Number:J483.006G
Wikidata:Q82137222

Synonyms:143703-84-8;Pyridine, 4-[5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]-;DTXSID30357337

Suppliers and Price of Pyridine, 4-[5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Pyridine, 4-[5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]-

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:291.06194637
Heavy Atom Count:21
Complexity:339

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NN=C(O2)C3=CC=NC=C3)C(F)(F)F

Technology Process of Pyridine, 4-[5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]-

There total 5 articles about Pyridine, 4-[5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 477886-85-4
5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

: 1692-15-5
4-pyridylboronic acid

: 143703-84-8
2-(pyridin-4-yl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Guidance literature:: With [2,2]bipyridinyl; potassium phosphate; copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 100 ℃; for 12h;
DOI:10.1016/j.tet.2012.12.080

Reference yield: 76.0%

: 54-85-3,7640-37-1
isoniazid

: 143703-88-2
O-ethyl 4-trifluoromethylbenzothioate

: 143703-84-8
2-(pyridin-4-yl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Guidance literature:: With acetic acid; In ethanol; at 80 ℃; for 24h;
DOI:10.1002/jhet.5570290454

Reference yield:

: 57870-03-8
O-ethyl 4-trifluoromethylbenzimidate

: 143703-84-8
2-(pyridin-4-yl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / hydrogen sulphide / pyridine / 2 h / 0 °C

2: 76 percent / acetic acid / ethanol / 24 h / 80 °C

With hydrogen sulfide; acetic acid; In pyridine; ethanol;
DOI:10.1002/jhet.5570290454