9H-Purine-9-ethanol, 6-amino-b-hexyl-, 4-methylbenzenesulfonate (ester), (R)-

Base Information

Chemical Name:9H-Purine-9-ethanol, 6-amino-b-hexyl-, 4-methylbenzenesulfonate (ester), (R)-
CAS No.:143707-24-8
Molecular Formula:C20H27N5O3S
Molecular Weight:417.532
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9H-Purine-9-ethanol, 6-amino-b-hexyl-, 4-methylbenzenesulfonate (ester), (R)-

Chemical Property:

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Technology Process of 9H-Purine-9-ethanol, 6-amino-b-hexyl-, 4-methylbenzenesulfonate (ester), (R)-

There total 10 articles about 9H-Purine-9-ethanol, 6-amino-b-hexyl-, 4-methylbenzenesulfonate (ester), (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 143788-69-6
N₆-benzoyl-9-<1,2(S)-dihydroxy-3(R)-nonyl>adenine

: 98-59-9
p-toluenesulfonyl chloride

: 143707-24-8
9-<1-(tosyloxy)-2(R)-octyl>adenine

Guidance literature:: With pyridine; In dichloromethane; at 50 ℃;
DOI:10.1021/jm00100a025

Reference yield:

: 6393-56-2
pentylmagnesium chloride

: 143707-24-8
9-<1-(tosyloxy)-2(R)-octyl>adenine

Guidance literature:: Multi-step reaction with 10 steps

1: 96 percent / lithium tetrachlorocuprate / diethyl ether / - 78 deg C, 3 h, then RT, 1 h

2: 84 percent / pyridine / CH₂Cl₂ / 50 °C

3: 96 percent / NaN₃ / dimethylformamide / 0.75 h / Heating

4: 98 percent / LiAlH₄ / diethyl ether / 2 h / Heating

5: 56 percent / n-Bu₃N / pentan-1-ol / 30 h / Heating

6: 58 percent / conc. HCl / 24 h / Ambient temperature

7: 90 percent / liq. NH₃ / 24 h / 90 °C

8: 63 percent / pyridine / CH₂Cl₂ / 48 h

9: 71 percent / conc. HCl / aq. ethanol / 24 h / Ambient temperature

10: 96 percent / pyridine / CH₂Cl₂ / 50 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sodium azide; dilithium tetrachlorocuprate; tributyl-amine; ammonia; In diethyl ether; ethanol; dichloromethane; pentan-1-ol; N,N-dimethyl-formamide;
DOI:10.1021/jm00100a025

Reference yield:

: 143707-07-7
1-[2,2-dimethyl-(4S)-1,3-dioxolan-4-yl]-(1S)-heptan-1-ol

: 143707-24-8
9-<1-(tosyloxy)-2(R)-octyl>adenine

Guidance literature:: Multi-step reaction with 9 steps

1: 84 percent / pyridine / CH₂Cl₂ / 50 °C

2: 96 percent / NaN₃ / dimethylformamide / 0.75 h / Heating

3: 98 percent / LiAlH₄ / diethyl ether / 2 h / Heating

4: 56 percent / n-Bu₃N / pentan-1-ol / 30 h / Heating

5: 58 percent / conc. HCl / 24 h / Ambient temperature

6: 90 percent / liq. NH₃ / 24 h / 90 °C

7: 63 percent / pyridine / CH₂Cl₂ / 48 h

8: 71 percent / conc. HCl / aq. ethanol / 24 h / Ambient temperature

9: 96 percent / pyridine / CH₂Cl₂ / 50 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sodium azide; tributyl-amine; ammonia; In diethyl ether; ethanol; dichloromethane; pentan-1-ol; N,N-dimethyl-formamide;
DOI:10.1021/jm00100a025