Technology Process of 1H-Isoindole-1,3(2H)-dione,
2-[3-(5-ethyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinyl)propyl]-
There total 9 articles about 1H-Isoindole-1,3(2H)-dione,
2-[3-(5-ethyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinyl)propyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine hydrochloride;
at 150 ℃;
for 0.166667h;
DOI:10.1021/jm00099a006
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) THF, 0.5 h, 2.) THF, overnight
2: 219 mg / H2, hydrogen chloride / 5 percent Pd/C / methanol / 20 h / 760 Torr
3: 61 percent / ethanol
4: 32 percent / pyridine hydrochloride / 0.17 h / 150 °C
With
hydrogenchloride; hydrogen; pyridine hydrochloride; sodium hydride;
palladium on activated charcoal;
In
methanol; ethanol;
DOI:10.1021/jm00099a006
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 61 percent / phosphorus pentachloride / 1 h / 120 °C
2: 94 percent / methanol / Heating
3: 62 percent / diisobutylaluminum hydride / tetrahydrofuran / 4 h / 0 °C
4: 1.) NaH / 1.) THF, 0.5 h, 2.) THF, overnight
5: 219 mg / H2, hydrogen chloride / 5 percent Pd/C / methanol / 20 h / 760 Torr
6: 61 percent / ethanol
7: 32 percent / pyridine hydrochloride / 0.17 h / 150 °C
With
hydrogenchloride; phosphorus pentachloride; hydrogen; pyridine hydrochloride; sodium hydride; diisobutylaluminium hydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00099a006
