N-(4-((5-(((Cyclopentyloxy)carbonyl)amino)benzo(b)thien-3-yl)methyl)-3 -methoxybenzoyl)benzenesulfonamide

Base Information

• Chemical Name: N-(4-((5-(((Cyclopentyloxy)carbonyl)amino)benzo(b)thien-3-yl)methyl)-3 -methoxybenzoyl)benzenesulfonamide
• CAS No.: 107786-74-3
• Molecular Formula: C29H28 N2 O6 S2
• Molecular Weight: 564.6724
• Mol file: 107786-74-3.mol

Synonyms:5-Cpcab;

Chemical Property of N-(4-((5-(((Cyclopentyloxy)carbonyl)amino)benzo(b)thien-3-yl)methyl)-3 -methoxybenzoyl)benzenesulfonamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 154.40000
• Density: 1.41g/cm³
• LogP: 7.77970

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-((5-(((Cyclopentyloxy)carbonyl)amino)benzo(b)thien-3-yl)methyl)-3 -methoxybenzoyl)benzenesulfonamide

There total 9 articles about N-(4-((5-(((Cyclopentyloxy)carbonyl)amino)benzo(b)thien-3-yl)methyl)-3 -methoxybenzoyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

benzenesulfonamide (98-10-2) + 4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoic acid (107786-73-2) → N-[4-[5-(cyclopentyloxycarbonyl)aminobenzo[b]thien-3-ylmethyl]-3-methoxybenzoyl]benzenesulphonamide (107786-74-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 48h;

DOI:10.1021/jm00171a043

Reference yield: 51.0%

→ N-[4-[5-(cyclopentyloxycarbonyl)aminobenzo[b]thien-3-ylmethyl]-3-methoxybenzoyl]benzenesulphonamide (107786-74-3)

Guidance literature:

Reference yield:

methyl 5-nitrobenzo[b]thiophene-2-carboxylate (20699-86-9) → N-[4-[5-(cyclopentyloxycarbonyl)aminobenzo[b]thien-3-ylmethyl]-3-methoxybenzoyl]benzenesulphonamide (107786-74-3)

Guidance literature:

Multi-step reaction with 7 steps

1: aq. LiOH / tetrahydrofuran; methanol / 4 h

2: Cu⁰, quinoline / 170 - 180 °C

3: 30 percent / SnCl₄ / CH₂Cl₂ / 18 h / Heating

4: 54 percent / SnCl₂*2H₂O / ethanol / 2 h / Heating

5: 78 percent / 2,6-lutidine / CH₂Cl₂ / 24 h

6: 95 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h

7: 51 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h

With 2,6-dimethylpyridine; quinoline; dmap; lithium hydroxide; tin(IV) chloride; copper; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1021/jm00171a043

upstream raw materials:

benzenesulfonamide

4-<<5-<<(cyclopentyloxy)carbonyl>amino>benzothien-3-yl>methyl>-3-methoxybenzoic acid

methyl 5-nitrobenzo[b]thiophene-2-carboxylate

5-nitrobenzo[b]thiophene

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