4-(Boc-amino)tetrahydropyran-4-carboxylic acid

Base Information

Chemical Name:4-(Boc-amino)tetrahydropyran-4-carboxylic acid
CAS No.:172843-97-9
Molecular Formula:C11H19 N O5
Molecular Weight:245.276
Hs Code.:29225000
European Community (EC) Number:681-429-6
DSSTox Substance ID:DTXSID50361471
Wikidata:Q72510001
Mol file:172843-97-9.mol

Synonyms:172843-97-9;4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN;4-(Boc-amino)tetrahydropyran-4-carboxylic acid;4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylic acid;4-[(2-methylpropan-2-yl)oxycarbonylamino]oxane-4-carboxylic Acid;MFCD02683136;4-{[(tert-butoxy)carbonyl]amino}oxane-4-carboxylic acid;4-[(tert-butoxycarbonyl)amino]tetrahydro-2H-pyran-4-carboxylic acid;Boc-ThpGly-OH;SCHEMBL289956;DTXSID50361471;4-(TERT-BUTOXYCARBAMOYL)TETRAHYDROPYRAN-4-CARBOXYLIC ACID;4-(tert-butoxycarbonylamino)tetrahydro-2H-pyran-4-carboxylic acid;AMY37738;XGA84397;AKOS012536369;CS-W008506;PB15717;AS-42013;SY014577;EN300-114991;A881839;J-515852;4-[(tert-Butoxycarbonyl)amino]oxane-4-carboxylic acid;Z1200998567;4-tert-Butoxycarbonylamino-tetrahydro-pyran-4-carboxylic acid;4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylicacid;4-({[(1,1-Dimethylethyl)oxy]carbonyl}amino)tetrahydro-2H-pyran-4-carboxylic acid

Suppliers and Price of 4-(Boc-amino)tetrahydropyran-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(Boc-amino)tetrahydropyran-4-carboxylicAcid
100mg
$ 60.00

TRC
4-(Boc-amino)tetrahydropyran-4-carboxylicAcid
50mg
$ 45.00

Matrix Scientific
4-(Boc-amino)tetrahydropyran-4-carboxylicacid 95+%
1g
$ 594.00

Crysdot
4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylicacid 97%
10g
$ 452.00

Crysdot
4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylicacid 97%
5g
$ 289.00

Apolloscientific
4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylicacid 97%
5g
$ 472.00

Apolloscientific
4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylicacid 97%
1g
$ 182.00

American Custom Chemicals Corporation
4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN 95.00%
10G
$ 3668.57

American Custom Chemicals Corporation
4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN 95.00%
5G
$ 2152.64

American Custom Chemicals Corporation
4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN 95.00%
1G
$ 1819.13

Total 27 raw suppliers

Chemical Property of 4-(Boc-amino)tetrahydropyran-4-carboxylic acid

Chemical Property:

Vapor Pressure:8.52E-08mmHg at 25°C
Melting Point:157℃
Refractive Index:1.4450 (estimate)
Boiling Point:407.9°Cat760mmHg
PKA:3.76±0.20(Predicted)
Flash Point:200.5°C
PSA：84.86000
Density:1.19g/cm³
LogP:1.53580
Storage Temp.:2-8°C
Water Solubility.:Soluble in water. (15 g/L) (25°C)
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:245.12632271
Heavy Atom Count:17
Complexity:302

Purity/Quality:

99%, ^*data from raw suppliers

4-(Boc-amino)tetrahydropyran-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1(CCOCC1)C(=O)O
Uses Used as pharmaceutical intermediate.

Technology Process of 4-(Boc-amino)tetrahydropyran-4-carboxylic acid

There total 9 articles about 4-(Boc-amino)tetrahydropyran-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 39124-19-1
8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione

: 24424-99-5
di-tert-butyl dicarbonate

: 172843-97-9
4-(Boc-amino)tetrahydropyran-4-carboxylic acid

Guidance literature:: 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione; With calcium hydroxide; water; for 48h; Reflux;

di-tert-butyl dicarbonate; With sodium hydroxide; In 1,4-dioxane; methanol; water; at 20 ℃; for 15h;

Reference yield: 62.0%

: t-butyl (4-vinyltetrahydro-2H-pyran-4-yl)carbamate

: 172843-97-9
4-(Boc-amino)tetrahydropyran-4-carboxylic acid

Guidance literature:: t-butyl (4-vinyltetrahydro-2H-pyran-4-yl)carbamate; With ozone; In dichloromethane; at -78 ℃;

With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In water; tert-butyl alcohol;
DOI:10.1021/acs.joc.5b02628