Ethyl 1-[(2-nitrophenyl)methyl]-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:Ethyl 1-[(2-nitrophenyl)methyl]-1H-pyrrole-2-carboxylate
CAS No.:143879-96-3
Molecular Formula:C14H14N2O4
Molecular Weight:274.276
Hs Code.:
DSSTox Substance ID:DTXSID10569097
Wikidata:Q82455810
Mol file:143879-96-3.mol

Synonyms:143879-96-3;Ethyl 1-[(2-nitrophenyl)methyl]-1H-pyrrole-2-carboxylate;DTXSID10569097

Suppliers and Price of Ethyl 1-[(2-nitrophenyl)methyl]-1H-pyrrole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 1-[(2-nitrophenyl)methyl]-1H-pyrrole-2-carboxylate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:274.09535693
Heavy Atom Count:20
Complexity:356

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CC=CN1CC2=CC=CC=C2[N+](=O)[O-]

Technology Process of Ethyl 1-[(2-nitrophenyl)methyl]-1H-pyrrole-2-carboxylate

There total 1 articles about Ethyl 1-[(2-nitrophenyl)methyl]-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 29872-21-7
o-nitrobenzyl iodide

: 2199-43-1
ethyl 1H-pyrrole-2-carboxylate

: 143879-96-3
ethyl 1-(2-nitrobenzyl)-2-pyrrolecarboxylate

Guidance literature:: With 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; for 2.5h; Ambient temperature;
DOI:10.1002/jhet.5570290457

Reference yield: 96.0%

: 143879-96-3
ethyl 1-(2-nitrobenzyl)-2-pyrrolecarboxylate

: 143879-97-4
ethyl 1-(2-aminobenzyl)-2-pyrrolecarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; at 45 ℃; for 3h; under 2585.7 Torr;
DOI:10.1002/jhet.5570290457

Reference yield:

: 143879-96-3
ethyl 1-(2-nitrobenzyl)-2-pyrrolecarboxylate

: 73033-45-1
1-(2-aminobenzyl)-2-pyrrolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / H₂ / 10percent Pd/C / ethyl acetate; ethanol / 3 h / 45 °C / 2585.7 Torr

2: 69 percent / potassium hydroxide / ethanol / 1 h / Heating

With potassium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1002/jhet.5570290457