desacetyl-alacepril

Base Information

Chemical Name:desacetyl-alacepril
CAS No.:74259-08-8
Molecular Formula:C18H24 N2 O4 S
Molecular Weight:364.466
Hs Code.:
Mol file:74259-08-8.mol

Synonyms:L-Phenylalanine,N-[1-(3-mercapto-2-methyl-1-oxopropyl)-L-prolyl]-, (S)-; DU 1227; Desacetylalacepril

Suppliers and Price of desacetyl-alacepril

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of desacetyl-alacepril

Chemical Property:

Vapor Pressure:6.97E-18mmHg at 25°C
Boiling Point:651.9°C at 760 mmHg
Flash Point:348.1°C
PSA：129.00000
Density:1.268g/cm³
LogP:2.13360

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of desacetyl-alacepril

There total 10 articles about desacetyl-alacepril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 74258-86-9
alacepril

: 74259-08-8
1-((S)-3-mercapto-2-methylpropanoyl)-L-prolyl-L-phenylalanine

Guidance literature:: With ammonium hydroxide; for 2h; Ambient temperature;
DOI:10.1248/cpb.38.529

Reference yield:

: 64806-05-9
Captopril disulfide

: 74259-08-8
1-((S)-3-mercapto-2-methylpropanoyl)-L-prolyl-L-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / chloroform / 0.33 h / 0 °C / Inert atmosphere

1.2: 10 h / 0 - 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / ethanol / 3 h / Inert atmosphere

3.1: sodium tetrahydroborate / Inert atmosphere

With sodium tetrahydroborate; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; lithium hydroxide; In ethanol; chloroform;
DOI:10.1039/c1ob05148b

Reference yield:

: 1316643-70-5
C₃₈H₅₀N₄O₈S₂

: 74259-08-8
1-((S)-3-mercapto-2-methylpropanoyl)-L-prolyl-L-phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / ethanol / 3 h / Inert atmosphere

2: sodium tetrahydroborate / Inert atmosphere

With sodium tetrahydroborate; water; lithium hydroxide; In ethanol;
DOI:10.1039/c1ob05148b