4,6-Dichloroquinazoline

Base Information

• Chemical Name: 4,6-Dichloroquinazoline
• CAS No.: 7253-22-7
• Molecular Formula: C8H4Cl2N2
• Molecular Weight: 199.039
• Hs Code.: 2933990090
• Mol file: 7253-22-7.mol

Synonyms:NSC 58591;

Chemical Property of 4,6-Dichloroquinazoline

Chemical Property:

• Melting Point: 155-156 °C
• Boiling Point: 305.7 °C at 760 mmHg
• PKA: 0.11±0.30(Predicted)
• Flash Point: 167.3 °C
• PSA: 25.78000
• Density: 1.486 g/cm³
• LogP: 2.93660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4,6-Dichloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4,6-Dichloroquinazoline

There total 8 articles about 4,6-Dichloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-chloro-4-hydroxyquinazoline (16064-14-5) → 4,6-dichloroquinazoline (7253-22-7)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; at 110 ℃;

Reference yield: 80.0%

6-chloroquinazolin-4-one (16064-14-5) → 4,6-dichloroquinazoline (7253-22-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; for 2.5h; Reflux;

DOI:10.1080/00397911.2010.519843

Reference yield: 46.0%

6-chloroquinazolin-4-one (16064-14-5) → 4,6-dichloroquinazoline (7253-22-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 100 ℃; for 1h;

upstream raw materials:

6-chloroquinazolin-4-one

6-chloro-4-hydroxyquinazoline

formamide

5-chloroanthranilic acid

Downstream raw materials:

4-ethoxy-6-chloro-quinazoline

N-(6-chloro-quinazolin-4-yl)-ethylenediamine

4-[[3,4-(methylenedioxy)benzyl]amino]-6-chloroquinazoline

6-chloro-4-methoxyquinazoline

Refernces

• 1、 Zhang, Zixue,Zhang, Qingwei,Zhang, Hao,Jiao, Minru,Guo, Zheng,Peng, Xinyan,Fu, Lei,Li, Jianqi. "Discovery of quinazolinyl-containing benzamides derivatives as novel HDAC1 inhibitors with in vitro and in vivo antitumor activities". . . Retrieved 2021/10/16.
• 2、 Lan, Ta Thu,Anh, Duong Tien,Pham-The, Hai,Dung, Do Thi Mai,Park, Eun Jae,Jang, Sun Dong,Kwon, Joo Hee,Kang, Jong Soon,Thuan, Nguyen Thi,Han, Sang-Bae,Nam, Nguyen-Hai. "Design, Synthesis and Bioevaluation of Two Series of 3-[(1-Benzyl-1H-1,2,3-triazol-4-yl)methyl]quinazolin-4(3H)-ones and N-(1-Benzylpiperidin-4-yl)quinazolin-4-amines". . . Retrieved 2020/07/06.