5,5-Dimethyl-3-(4-fluorophenyl)cyclohex-2-enone

Base Information

• Chemical Name: 5,5-Dimethyl-3-(4-fluorophenyl)cyclohex-2-enone
• CAS No.: 72036-55-6
• Molecular Formula: C14H15 F O
• Molecular Weight: 218.271
• Mol file: 72036-55-6.mol

Synonyms:3-(4-Fluorophenyl)-5,5-dimethyl-2-cyclohexenone

Chemical Property of 5,5-Dimethyl-3-(4-fluorophenyl)cyclohex-2-enone

Chemical Property:

• Vapor Pressure: 0.0021mmHg at 25°C
• Boiling Point: 290.2°C at 760 mmHg
• Flash Point: 142.7°C
• PSA: 17.07000
• Density: 1.085g/cm³
• LogP: 3.59820

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,5-Dimethyl-3-(4-fluorophenyl)cyclohex-2-enone

There total 1 articles about 5,5-Dimethyl-3-(4-fluorophenyl)cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

4-fluoroboronic acid (1765-93-1) + dimedone (126-81-8) → 3-(p-fluorophenyl)-5,5-dimethyl-2-cyclohexen-1-one (72036-55-6)

Guidance literature:

dimedone; With potassium carbonate; p-toluenesulfonyl chloride; In 1,4-dioxane; water;

4-fluoroboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; for 2h; Reflux;

Reference yield:

3-(p-fluorophenyl)-5,5-dimethyl-2-cyclohexen-1-one (72036-55-6) → 3-(4-Fluoro-phenyl)-5,5-dimethyl-cyclohex-2-enol

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; In 1,4-dioxane; water; at 24.9 ℃; Rate constant;

DOI:10.1039/P29860001327

upstream raw materials:

4-fluoroboronic acid

dimedone

Refernces