Trilobine

Base Information

Chemical Name:Trilobine
CAS No.:6138-73-4
Molecular Formula:C35H34 N2 O5
Molecular Weight:562.665
Hs Code.:
UNII:6H8V6C2Q77
DSSTox Substance ID:DTXSID90976922
Nikkaji Number:J8.347J
Wikidata:Q27108483
ChEMBL ID:CHEMBL500324

Synonyms:trilobine;trilobine sulfate

Suppliers and Price of Trilobine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TRILOBINE 95.00%
5MG
$ 502.49

Total 4 raw suppliers

Chemical Property of Trilobine

Chemical Property:

Melting Point:237°
PSA：61.42000
Density:1.242g/cm3
LogP:7.17540
XLogP3:5.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:562.24677219
Heavy Atom Count:42
Complexity:929

Purity/Quality:

98% ^*data from raw suppliers

TRILOBINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC2=CC3=C4C=C2C1CC5=CC(=C(C=C5)OC)OC6=CC=C(CC7C8=C(O4)C(=C(C=C8CCN7)OC)O3)C=C6
Isomeric SMILES:CN1CCC2=CC3=C4C=C2[C@@H]1CC5=CC(=C(C=C5)OC)OC6=CC=C(C[C@H]7C8=C(O4)C(=C(C=C8CCN7)OC)O3)C=C6
Description A bisbenzylisoquinoline alkaloid, this base has been isolated from Cocculus sarmentosus Diels and C. trilobus DC. It crystallizes as colourless prisms and is dextrorotatory with [α]29D + 296.3° (CHCI3). Both the hydrochloride and hydro_x0002_bromide are crystalline and sparingly soluble in H20 and the dimethiodide has m.p. 273°C (dec.). Two methoxyl groups and two methylimino groups are present. With dimethyl sulphate in NaOH, the base yields trilobinemethylmethine as long, colourless prisms, m.p. 106° C which is optically inactive and on ozonization furnishes 2-methoxy-5:4'-dialdehydodiphenyl ether, m.p. 72-5°C and a complex dialdehyde, m.p. 124°C.

Technology Process of Trilobine

There total 9 articles about Trilobine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: C₃₆H₃₆N₂O₇

: 26195-62-0
(+)-isotrilobine

: nortrilobine

: 54352-71-5
(+)-O-methyl cocsoline

: 6138-73-4
trilobine

Guidance literature:: With ferrous(II) sulfate heptahydrate; In methanol; at 20 ℃; for 48h; Cooling with ice;

Reference yield:

: 61897-94-7
2-benzoyl-6,7,6',12'-tetramethoxy-oxyacanth-1'-ene

: 6138-73-4
trilobine

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄

2: LiAlH₄, AlCl₃

3: (i) BBr₃, CH₂Cl₂, (ii) aq. HBr, (iii) /BRN= 102415/

4: H₂ / Pd-C

With sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; hydrogen; palladium on activated charcoal;
DOI:10.1016/S0040-4039(01)85520-9

Reference yield:

: 61897-93-6
2-benzoyl-6,7,6',12'-tetramethoxy-1',17'-seco-oxyacanthan-1'-one

: 6138-73-4
trilobine

Guidance literature:: Multi-step reaction with 5 steps

1: POCl₃

2: NaBH₄

3: LiAlH₄, AlCl₃

4: (i) BBr₃, CH₂Cl₂, (ii) aq. HBr, (iii) /BRN= 102415/

5: H₂ / Pd-C

With sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; hydrogen; trichlorophosphate; palladium on activated charcoal;
DOI:10.1016/S0040-4039(01)85520-9