Azinox

Base Information

• Chemical Name: Azinox
• CAS No.: 135526-78-2
• Molecular Formula: C19H24N2O2
• Molecular Weight: 312.40606
• Mol file: 135526-78-2.mol

Synonyms:Cesol;Pyquiton;Drontsit;Traziquantel;Biltricide;Droncit;Biliricide;Prasiquantel;

Chemical Property of Azinox

Chemical Property:

• Boiling Point: 544.1°Cat760mmHg
• Flash Point: 254.6°C
• PSA: 40.62000
• Density: 1.22g/cm³
• LogP: 2.41070

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Azinox

There total 178 articles about Azinox which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(cyclohexylcarbonyl)-6-hydroxy-1-phenethylpiperazine-2-one (87693-75-2) → 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one (55268-74-1,135526-78-2,57452-31-0,57452-98-9)

Guidance literature:

With hydrogenchloride; at 0 ℃;

Reference yield: 95.0%

4-(cyclohexylcarbonyl)-6-hydroxy-1-phenethylpiperazine-2-one (87693-75-2) → 2-(cyclohexylcarbonyl)-1,3,4,6,7,11b-hexahydro-2H-pyrazino-(2,1-a)-4-isoquinoleinone (PRAZIQUANTEL) + 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one (55268-74-1,135526-78-2,57452-31-0,57452-98-9)

Guidance literature:

In 12N-hydrochloric acid;

Reference yield: 93.0%

2-(Cyclohexylcarbonyl)-2,3,6,7-tetrahydro-4H-pyrazino-<2,1-a>-isoquinolin-4-one (125273-86-1) → 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one (55268-74-1,135526-78-2,57452-31-0,57452-98-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 19h; under 760.051 Torr; Solvent; Inert atmosphere;

DOI:10.1016/j.tet.2017.10.006

upstream raw materials:

N-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)cyclohexanecarboxylic acid amide

chloroacetyl chloride

1-Cyclohexylcarbonylaminomethyl-2-chloracetyl-1,2,3,4-tetrahydro-isochinolin

Cyclohexanecarboxylic acid bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl-[(methoxymethyl-carbamoyl)-methyl]-amide

Downstream raw materials:

2-(4-trans-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

2-(4-cis-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

(-)-2-Benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline

C₁₉H₂₆N₂O

Refernces

• 1、 Kim, Joong Hyup,Lee, Yong Sup,Park, Hokoon,Kim, Choong Sup. "Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization: An efficient synthesis of Praziquantel". . p. 7395 - 7400. Retrieved 1998.
• 2、 Zhang, Mei,Chen, Xinglian,Zhang, Junhui,Kong, Jiao,Yuan, Liming. "A 3D Homochiral MOF [Cd2(d-cam)3]?2Hdma?4dma for HPLC Chromatographic Enantioseparation". . p. 340 - 346. Retrieved 2016.
• 3、 Seubert et al.. "-". . p. 1036. Retrieved 1977.
• 4、 Gong, Bolin,Guo, Siyu,Zhang, Ning. "Preparation of a novel bridged bis(β-cyclodextrin) chiral stationary phase by thiol-ene click chemistry for enhanced enantioseparation in HPLC". . p. 35754 - 35764. Retrieved 2021/12/02.