Methyl 2-chloro-3-cyano-6-methylisonicotinate

Base Information

Chemical Name:Methyl 2-chloro-3-cyano-6-methylisonicotinate
CAS No.:59225-10-4
Molecular Formula:C9H7ClN2O2
Molecular Weight:210.6171
Hs Code.:2933399090
NSC Number:123102
DSSTox Substance ID:DTXSID70298437
Wikidata:Q82040248
Mol file:59225-10-4.mol

Synonyms:methyl 2-chloro-3-cyano-6-methylisonicotinate;59225-10-4;methyl 2-chloro-3-cyano-6-methylpyridine-4-carboxylate;NSC123102;DTXSID70298437;NWWBHRSPKWWFEO-UHFFFAOYSA-N;METHYL 2-CHLORO-3-CYANO-6-METHYL-PYRIDINE-4-CARBOXYLATE;BBL032441;STL243058;AKOS002683762;NSC-123102;VS-11256;CS-0326909;F2185-1592

Suppliers and Price of Methyl 2-chloro-3-cyano-6-methylisonicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Methyl 2-chloro-3-cyano-6-methylisonicotinate

Chemical Property:

Vapor Pressure:6.07E-06mmHg at 25°C
Boiling Point:378.9°Cat760mmHg
Flash Point:183°C
PSA：62.98000
Density:1.34g/cm³
LogP:1.70168
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:210.0196052
Heavy Atom Count:14
Complexity:273

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C(=N1)Cl)C#N)C(=O)OC

Technology Process of Methyl 2-chloro-3-cyano-6-methylisonicotinate

There total 6 articles about Methyl 2-chloro-3-cyano-6-methylisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 69155-31-3
4-oxopentane-1,1,2,2-tetracarbonitrile

: 59225-10-4
methyl 2-chloro-3-cyano-6-methylpyridine-4-carboxylate

Guidance literature:: With hydrogenchloride; methanol; water; at 50 ℃;
DOI:10.1134/S1070428016070071

Reference yield:

: 40108-12-1
ethyl 2-chloro-3-cyano-6-methyl-4-pyridine carboxylate

: 59225-10-4
methyl 2-chloro-3-cyano-6-methylpyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: aqueous NH₃

2: aqueous HCl

With hydrogenchloride; ammonium hydroxide;
DOI:10.1021/jo01197a010

Reference yield:

: 18619-97-1
ethyl 3-cyano-2-hydroxy-6-methylisonicotinate

: 59225-10-4
methyl 2-chloro-3-cyano-6-methylpyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: PCl₅; POCl₃

2: aqueous NH₃

3: aqueous HCl

With hydrogenchloride; ammonium hydroxide; phosphorus pentachloride; trichlorophosphate;
DOI:10.1021/jo01197a010