Propanoic acid, 2-[[1-[(4-chlorophenyl)methyl]-2-(3-cyano-2,2-dimethylpropyl)-5-methoxy -1H-indol-3-yl]thio]-, (R)-

Base Information

Chemical Name:Propanoic acid, 2-[[1-[(4-chlorophenyl)methyl]-2-(3-cyano-2,2-dimethylpropyl)-5-methoxy -1H-indol-3-yl]thio]-, (R)-
CAS No.:144174-40-3
Molecular Formula:C25H27ClN2O3S
Molecular Weight:471.02
Hs Code.:
Mol file:144174-40-3.mol

Synonyms:

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Chemical Property of Propanoic acid, 2-[[1-[(4-chlorophenyl)methyl]-2-(3-cyano-2,2-dimethylpropyl)-5-methoxy -1H-indol-3-yl]thio]-, (R)-

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Technology Process of Propanoic acid, 2-[[1-[(4-chlorophenyl)methyl]-2-(3-cyano-2,2-dimethylpropyl)-5-methoxy -1H-indol-3-yl]thio]-, (R)-

There total 4 articles about Propanoic acid, 2-[[1-[(4-chlorophenyl)methyl]-2-(3-cyano-2,2-dimethylpropyl)-5-methoxy -1H-indol-3-yl]thio]-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 62646-04-2
1-(4-chlorobenzyl)-1-(4-methoxyphenyl)hydrazine

: 144174-43-6
(R)-2-(5-Cyano-4,4-dimethyl-2-oxo-pentylsulfanyl)-propionic acid

: 144174-40-3
(R)-2-[1-(4-Chloro-benzyl)-2-(3-cyano-2,2-dimethyl-propyl)-5-methoxy-1H-indol-3-ylsulfanyl]-propionic acid

Guidance literature:: With acetic acid; In toluene; for 48h; Ambient temperature;
DOI:10.1016/S0040-4039(00)61267-4

Reference yield:

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 144174-40-3
(R)-2-[1-(4-Chloro-benzyl)-2-(3-cyano-2,2-dimethyl-propyl)-5-methoxy-1H-indol-3-ylsulfanyl]-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / NEt₃ / toluene / 3 h / Heating

2: 85 percent / acetic acid / toluene / 48 h / Ambient temperature

With acetic acid; triethylamine; In toluene;
DOI:10.1016/S0040-4039(00)61267-4

Reference yield:

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 144174-40-3
(R)-2-[1-(4-Chloro-benzyl)-2-(3-cyano-2,2-dimethyl-propyl)-5-methoxy-1H-indol-3-ylsulfanyl]-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / NEt₃ / toluene / 3 h / Heating

2: 85 percent / acetic acid / toluene / 48 h / Ambient temperature

With acetic acid; triethylamine; In toluene;
DOI:10.1016/S0040-4039(00)61267-4