Technology Process of 1,3,2-Dioxaborolane, 2-(4-azidobutyl)-4,4,5,5-tetramethyl-
There total 1 articles about 1,3,2-Dioxaborolane, 2-(4-azidobutyl)-4,4,5,5-tetramethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
MgSO4; nBu4NBr;
In
Dimethyl ether; water; ethyl acetate;
Br(CH2)4B(OH)2 reacted with pinacol and MgSO4 in Et2O at room temp., then react. with nBu4NBr and NaN3 in H2O/EtOAc at 80°C for 16 h; 99% ee;
DOI:10.1002/anie.201006037
- Guidance literature:
-
(S)-(-)-1-phenylethyl N,N-diisopropylcarbamate;
With
sec.-butyllithium;
In
diethyl ether; hexane; cyclohexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
2-(4'-azidobutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;
With
magnesium bromide;
In
methanol; diethyl ether; hexane; cyclohexane;
at -78 - 25 ℃;
for 17.3333h;
Inert atmosphere;
DOI:10.1002/anie.201006037
- Guidance literature:
-
3-(4-methoxyphenyl)propyl N,N-diisopropylcarbamate;
With
sec.-butyllithium; (-)-sparteine;
In
diethyl ether; hexane; cyclohexane;
at -78 ℃;
for 5h;
2-(4'-azidobutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;
In
diethyl ether; hexane; cyclohexane;
at -78 - 20 ℃;
With
magnesium bromide ethyl etherate;
In
diethyl ether; hexane; cyclohexane;
for 16h;
Reflux;
DOI:10.1021/ja2077813
