(E)-tert-Butyl 3-(4-formylphenyl)acrylate

Base Information

• Chemical Name: (E)-tert-Butyl 3-(4-formylphenyl)acrylate
• CAS No.: 144374-53-8
• Molecular Formula: C14H16O3
• Molecular Weight: 232.279
• Hs Code.: 2918300090
• Mol file: 144374-53-8.mol

Synonyms:3-(4-fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 3-(4-fluorobenzyl)piperidine-1-carboxylate;4-[2-(tert-butoxycarbonyl)ethenyl]benzaldehyde;3-(4-formyl-phenyl)-acrylic acid tert-butyl ester;N-BOC-3-(4-FLUOROBENZYL)PIPERIDINE;tert-Butyl 3-(4-fluorobenzyl)-1-piperidinecarboxylate;t-Butyl (+)-3-(4-fluorobenzyl)-1-piperidinecarboxylate;tert-butyl 3-(4-formylphenyl)acrylate;

Chemical Property of (E)-tert-Butyl 3-(4-formylphenyl)acrylate

Chemical Property:

• PSA: 43.37000
• LogP: 2.85400
• Storage Temp.: Refrigerated.

Purity/Quality:

≥95% ^*data from raw suppliers

(E)-tert-Butyl3-(4-formylphenyl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-tert-Butyl 3-(4-formylphenyl)acrylate

There total 4 articles about (E)-tert-Butyl 3-(4-formylphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 4-bromo-benzaldehyde (1122-91-4) → 4-[2-(tert-butoxycarbonyl)ethenyl]benzaldehyde (144374-53-8)

Guidance literature:

With C₆₄H₅₂N₆O₆Pd₂; sodium acetate; In N,N-dimethyl-formamide; at 140 ℃; for 20h; Inert atmosphere;

DOI:10.1055/s-2008-1067199

Reference yield: 71.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 4-chlorobenzaldehyde (104-88-1) → 4-[2-(tert-butoxycarbonyl)ethenyl]benzaldehyde (144374-53-8)

Guidance literature:

With potassium carbonate; In water; at 90 ℃; for 12h; Green chemistry;

DOI:10.1002/aoc.3762

Reference yield:

terephthalaldehyde, (623-27-8) + (tert-butoxycarbonylmethyl)triphenylphosphonium bromide (59159-39-6) → 4-[2-(tert-butoxycarbonyl)ethenyl]benzaldehyde (144374-53-8)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at 0 - 5 ℃; for 0.25h;

DOI:10.1080/00397910802638560

upstream raw materials:

tert-Butyl acrylate

4-bromo-benzaldehyde

terephthalaldehyde,

(tert-butoxycarbonylmethyl)triphenylphosphonium bromide

Downstream raw materials:

4-[4-(2-tert-butoxycarbonylvinyl)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

4-[4-(2-tert-Butoxycarbonyl-vinyl)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

3-{4-[3-(3,4-difluoro-phenyl)-3-oxo-propenyl]-phenyl}-acrylic acid tert-butyl ester