Phosphonic acid, [5-(1,1-dimethylethyl)-2-[(1,4,7,10,13-pentaoxacyclopentadec-1-ylmeth oxy)methyl]phenyl]-, monoethyl ester, sodium salt

Base Information

• Chemical Name: Phosphonic acid, [5-(1,1-dimethylethyl)-2-[(1,4,7,10,13-pentaoxacyclopentadec-1-ylmeth oxy)methyl]phenyl]-, monoethyl ester, sodium salt
• CAS No.: 144381-50-0
• Molecular Formula: C₂₄H₄₀O₉P*Na
• Molecular Weight: 526.54
• Mol file: 144381-50-0.mol

Synonyms:

Chemical Property of Phosphonic acid, [5-(1,1-dimethylethyl)-2-[(1,4,7,10,13-pentaoxacyclopentadec-1-ylmeth oxy)methyl]phenyl]-, monoethyl ester, sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphonic acid, [5-(1,1-dimethylethyl)-2-[(1,4,7,10,13-pentaoxacyclopentadec-1-ylmeth oxy)methyl]phenyl]-, monoethyl ester, sodium salt

There total 7 articles about Phosphonic acid, [5-(1,1-dimethylethyl)-2-[(1,4,7,10,13-pentaoxacyclopentadec-1-ylmeth oxy)methyl]phenyl]-, monoethyl ester, sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-(Bromomethyl)-5-t-butylbenzenephosphonic acid monoethyl ester (98910-95-3) + Hydroxymethyl-15-crown-5 → sodium monoethyl 5-tert-butyl-1-(oxymethyl-15-crown-5)methylbenzenephosphonate (144381-50-0)

Guidance literature:

With potassium hydride; In tetrahydrofuran; for 96h; Heating;

DOI:10.1039/c39850000990

Reference yield:

4-(tert-butyl)-2-iodo-1-methylbenzene (70728-98-2) → sodium monoethyl 5-tert-butyl-1-(oxymethyl-15-crown-5)methylbenzenephosphonate (144381-50-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / Cu powder / Heating

2: 85 percent / NaOH / aq. ethanol / Heating

3: 83 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / Heating

4: 36 percent / KH / tetrahydrofuran / 96 h / Heating

With sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; potassium hydride; copper; In tetrahydrofuran; tetrachloromethane; ethanol;

DOI:10.1039/c39850000990

Reference yield:

4-tert-butyltoluene (98-51-1) → sodium monoethyl 5-tert-butyl-1-(oxymethyl-15-crown-5)methylbenzenephosphonate (144381-50-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / periodic acid dihydrate, I₂, aq. H₂SO₄ / acetic acid / 60 - 65 °C

2: 72 percent / Cu powder / Heating

3: 85 percent / NaOH / aq. ethanol / Heating

4: 83 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / Heating

5: 36 percent / KH / tetrahydrofuran / 96 h / Heating

With sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; iodine; potassium hydride; periodic acid; copper; In tetrahydrofuran; tetrachloromethane; ethanol; acetic acid;

DOI:10.1039/c39850000990

upstream raw materials:

2-(hydroxymethyl)-15-crown-5

2-(Bromomethyl)-5-t-butylbenzenephosphonic acid monoethyl ester

4-tert-butyltoluene

4-(tert-butyl)-2-iodo-1-methylbenzene