1,3-Indandione, 2-(3-pyridylmethylene)-

Base Information

Chemical Name:1,3-Indandione, 2-(3-pyridylmethylene)-
CAS No.:31083-55-3
Molecular Formula:C15H9 N O2
Molecular Weight:235.25
Hs Code.:
NSC Number:600157
UNII:J625FJL5DX
DSSTox Substance ID:DTXSID90185032
Nikkaji Number:J3.361.340G
Wikidata:Q27281242
ChEMBL ID:CHEMBL4303151
Mol file:31083-55-3.mol

Synonyms:2-pyridine-3-yl-methylene-indan-1,3-dione;PRT4165

Suppliers and Price of 1,3-Indandione, 2-(3-pyridylmethylene)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PRT 4165
10mg
$ 310.00

Tocris
PRT4165 ≥99%(HPLC)
50
$ 363.00

Tocris
PRT4165 ≥99%(HPLC)
10
$ 87.00

Sigma-Aldrich
PRT4165 ≥98% (HPLC)
5mg
$ 88.80

Sigma-Aldrich
PRT4165 ≥98% (HPLC)
25mg
$ 349.00

DC Chemicals
PRT4165（NSC-600157） >98%
250 mg
$ 500.00

DC Chemicals
PRT4165（NSC-600157） >98%
100 mg
$ 250.00

CSNpharm
PRT4165
10mg
$ 60.00

CSNpharm
PRT4165
25mg
$ 96.00

CSNpharm
PRT4165
50mg
$ 153.00

Total 76 raw suppliers

Chemical Property of 1,3-Indandione, 2-(3-pyridylmethylene)-

Chemical Property:

Vapor Pressure:2.26E-08mmHg at 25°C
Refractive Index:1.6231 (estimate)
Boiling Point:452.3°Cat760mmHg
Flash Point:227°C
PSA：47.03000
Density:1.363g/cm³
LogP:2.54420
Storage Temp.:2-8°C
Solubility.:DMSO: soluble20mg/mL, clear
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:235.063328530
Heavy Atom Count:18
Complexity:373

Purity/Quality:

99%, ^*data from raw suppliers

PRT 4165 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=O)C(=CC3=CN=CC=C3)C2=O
Description PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50?= 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1?PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo?and as such represents a new tool for studying chromatin remodeling.2

Technology Process of 1,3-Indandione, 2-(3-pyridylmethylene)-

There total 3 articles about 1,3-Indandione, 2-(3-pyridylmethylene)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%