2H-Furo[3,2-e]indole-7-carboxylic acid, 6-[(4-chlorophenyl)methyl]-8-[(1,1-dimethylethyl)thio]-1,6-dihydro-2-meth yl-, ethyl ester

Base Information

Chemical Name:2H-Furo[3,2-e]indole-7-carboxylic acid, 6-[(4-chlorophenyl)methyl]-8-[(1,1-dimethylethyl)thio]-1,6-dihydro-2-meth yl-, ethyl ester
CAS No.:144397-05-7
Molecular Formula:C25H28ClNO3S
Molecular Weight:458.021
Hs Code.:
Mol file:144397-05-7.mol

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Chemical Property of 2H-Furo[3,2-e]indole-7-carboxylic acid, 6-[(4-chlorophenyl)methyl]-8-[(1,1-dimethylethyl)thio]-1,6-dihydro-2-meth yl-, ethyl ester

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Technology Process of 2H-Furo[3,2-e]indole-7-carboxylic acid, 6-[(4-chlorophenyl)methyl]-8-[(1,1-dimethylethyl)thio]-1,6-dihydro-2-meth yl-, ethyl ester

There total 4 articles about 2H-Furo[3,2-e]indole-7-carboxylic acid, 6-[(4-chlorophenyl)methyl]-8-[(1,1-dimethylethyl)thio]-1,6-dihydro-2-meth yl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 144397-03-5
4-Allyl-3-tert-butylsulfanyl-1-(4-chloro-benzyl)-5-hydroxy-1H-indole-2-carboxylic acid ethyl ester

: 144397-04-6
ethyl 1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indole-2-carboxylate

: 144397-05-7
8-tert-Butylsulfanyl-6-(4-chloro-benzyl)-2-methyl-1,2-dihydro-6H-furo[3,2-e]indole-7-carboxylic acid ethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1016/S0040-4039(00)61266-2

Reference yield:

: 70-23-5
ethyl Bromopyruvate

: 144397-05-7
8-tert-Butylsulfanyl-6-(4-chloro-benzyl)-2-methyl-1,2-dihydro-6H-furo[3,2-e]indole-7-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NEt₃ / tetrahydrofuran

2: 75 percent / NaOAc, HOAc / toluene / 80 °C

3: 70 percent / K₂CO₃ / various solvent(s) / 150 °C

4: p-TSA / CH₂Cl₂ / 24 h / Ambient temperature

With sodium acetate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)61266-2

Reference yield:

: 141863-12-9
ethyl 3-tert-butylthio-2-oxo-propionate

: 144397-05-7
8-tert-Butylsulfanyl-6-(4-chloro-benzyl)-2-methyl-1,2-dihydro-6H-furo[3,2-e]indole-7-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / NaOAc, HOAc / toluene / 80 °C

2: 70 percent / K₂CO₃ / various solvent(s) / 150 °C

3: p-TSA / CH₂Cl₂ / 24 h / Ambient temperature

With sodium acetate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)61266-2