6,7-Dimethoxy-2,3-dimethylquinoxaline

Base Information

• Chemical Name: 6,7-Dimethoxy-2,3-dimethylquinoxaline
• CAS No.: 32388-00-4
• Molecular Formula: C12H14N2O2
• Molecular Weight: 218.25
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90186100
• Nikkaji Number: J479.895C
• Wikidata: Q83057301
• Mol file: 32388-00-4.mol

Synonyms:6,7-dimethoxy-2,3-dimethylquinoxaline;6,7-DMODMQ

Chemical Property of 6,7-Dimethoxy-2,3-dimethylquinoxaline

Chemical Property:

• Vapor Pressure: 0.000396mmHg at 25°C
• Melting Point: 176-178°C
• Refractive Index: 1.578
• Boiling Point: 327 °C at 760 mmHg
• PKA: 1.60±0.48(Predicted)
• Flash Point: 119.8 °C
• PSA: 44.24000
• Density: 1.145 g/cm³
• LogP: 2.26380
• Storage Temp.: Refrigerator
• Solubility.: Chloroform
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 218.105527694
• Heavy Atom Count: 16
• Complexity: 213

Purity/Quality:

98.5% ^*data from raw suppliers

6,7-Dimethoxy-2,3-dimethyl-quinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC(=C(C=C2N=C1C)OC)OC
• Uses: 6,7-Dimethoxy-2,3-dimethyl-quinoxaline (cas# 32388-00-4) is a compound useful in organic synthesis.

Technology Process of 6,7-Dimethoxy-2,3-dimethylquinoxaline

There total 3 articles about 6,7-Dimethoxy-2,3-dimethylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-amino-5-nitroveratrol (7595-31-5) + dimethylglyoxal (431-03-8) → 2,3-Dimethyl-6,7-dimethoxy-chinoxalin (32388-00-4)

Guidance literature:

With indium; indium(III) chloride; In methanol; for 2h; Reflux; Inert atmosphere;

DOI:10.1016/j.tet.2015.01.007

Reference yield:

dimethylglyoxal (431-03-8) + 4,5-dimethoxybenzene-1,2-diamine (27841-33-4) → 2,3-Dimethyl-6,7-dimethoxy-chinoxalin (32388-00-4)

Guidance literature:

With acetic acid;

Reference yield:

→ 2,3-Dimethyl-6,7-dimethoxy-chinoxalin (32388-00-4)

Guidance literature:

4,5-Dinitroveratrol 11, 1) H2/Pd/C, 2) Diacetyl;

DOI:10.1002/hlca.19750580836

upstream raw materials:

dimethylglyoxal

4,5-dimethoxybenzene-1,2-diamine

4-amino-5-nitroveratrol

Refernces