Pyrido[4,3-d]pyrimidin-2-amine, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-, dihydrochloride

Base Information

• Chemical Name: Pyrido[4,3-d]pyrimidin-2-amine, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-, dihydrochloride
• CAS No.: 144507-19-7
• Molecular Formula: C13H13ClN4.2ClH
• Molecular Weight: 333.648
• Mol file: 144507-19-7.mol

Synonyms:

Chemical Property of Pyrido[4,3-d]pyrimidin-2-amine, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-, dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrido[4,3-d]pyrimidin-2-amine, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-, dihydrochloride

There total 4 articles about Pyrido[4,3-d]pyrimidin-2-amine, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-, dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-acetyl-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (144507-17-5) → 2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine dihydrochloride (144507-19-7)

Guidance literature:

With hydrogenchloride; for 12h; Heating;

DOI:10.1016/0223-5234(92)90085-F

Reference yield:

1-acetyl-4-piperidinone (32161-06-1) → 2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine dihydrochloride (144507-19-7)

Guidance literature:

Multi-step reaction with 6 steps

1: p-toluene sulfonic acid / benzene / 12 h / Heating

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 5percent HCl / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 58 percent / benzene / 5 h / Heating

5: 82 percent / C₂H₅ONa / ethanol / 3 h / Heating

6: 91 percent / 10percent aq. HCl / 12 h / Heating

With hydrogenchloride; sodium ethanolate; toluene-4-sulfonic acid; triethylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/0223-5234(92)90085-F

Reference yield:

1-(4-(morpholin-4-yl)-3,6-dihydro-2H-pyridin-1-yl)ethanone (55459-60-4) → 2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine dihydrochloride (144507-19-7)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 5percent HCl / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 58 percent / benzene / 5 h / Heating

4: 82 percent / C₂H₅ONa / ethanol / 3 h / Heating

5: 91 percent / 10percent aq. HCl / 12 h / Heating

With hydrogenchloride; sodium ethanolate; triethylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/0223-5234(92)90085-F

upstream raw materials:

6-acetyl-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

1-acetyl-4-piperidinone

1-(4-(morpholin-4-yl)-3,6-dihydro-2H-pyridin-1-yl)ethanone

Downstream raw materials:

2-Amino-4-(4-chlorophenyl)-6-propyl-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine Dihydrochloride

6-allyl-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride

2-amino-4-(4-chlorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

4-(4-Chloro-phenyl)-6-propyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-ylamine