chamaecynone

Base Information

• Chemical Name: chamaecynone
• CAS No.: 10208-54-5
• Molecular Formula: C₁₄H₁₈O
• Molecular Weight: 202.296
• Mol file: 10208-54-5.mol

Synonyms:2(1H)-Naphthalenone,7-ethynyl-4a,5,6,7,8,8a-hexahydro-1,4a-dimethyl-, [1S-(1a,4ab,7b,8ab)]-; 2(1H)-Naphthalenone, 7b-ethynyl-4a,5,6,7,8,8ab-hexahydro-1a,4ab-dimethyl- (8CI); Chamecynone (7CI); Chamaecynone

Chemical Property of chamaecynone

Chemical Property:

• Vapor Pressure: 0.00238mmHg at 25°C
• Boiling Point: 288.2°C at 760 mmHg
• Flash Point: 117.8°C
• PSA: 17.07000
• Density: 1.01g/cm³
• LogP: 2.81720

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of chamaecynone

There total 21 articles about chamaecynone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(+/-)-isochamaecynone → (+/-)-chamaecynone (10208-54-5,10208-55-6,17429-28-6,55220-87-6,65700-87-0,85248-95-9)

Guidance literature:

With potassium hydroxide; In ethanol; Ambient temperature;

Reference yield: 39.0%

2α-bromo-4βH,5β-13-noreudesm-11-yn-3-one (75520-65-9) → chamaecynone (10208-54-5)

Guidance literature:

With lithium bromide; In N,N-dimethyl-formamide; at 140 - 165 ℃; for 2h;

DOI:10.1246/bcsj.53.1425

Reference yield: 24.0%

4αH,5βH-13-noreudesm-11-yn-3-one (74806-70-5) → isochamaecynone (10208-55-6) + chamaecynone (10208-54-5) + dehydrochamaecynone + isodehydrochamaecynone (163890-62-8)

Guidance literature:

4αH,5βH-13-noreudesm-11-yn-3-one; With hydrogen bromide; bromine; acetic acid;

With lithium carbonate; lithium bromide; In N,N-dimethyl-formamide; Further stages.;

DOI:10.1021/np0205250

upstream raw materials:

isochamaecynone

4αH,5βH-13-noreudesm-11-yn-3-one

2α-bromo-4βH,5β-13-noreudesm-11-yn-3-one

(11S)-3-oxo-eudesma-1,4-dien-13-oic acid

Downstream raw materials:

isochamaecynone