1H-Imidazole-5-carboxylic acid, 2-butyl-1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-4- (1-hydroxy-1-methylethyl)-, ethyl ester

Base Information

Chemical Name:1H-Imidazole-5-carboxylic acid, 2-butyl-1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-4- (1-hydroxy-1-methylethyl)-, ethyl ester
CAS No.:144689-18-9
Molecular Formula:C31H40N2O5
Molecular Weight:520.669
Hs Code.:
Mol file:144689-18-9.mol

1H-Imidazole-5-carboxylic acid,
2-butyl-1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-4-
(1-hydroxy-1-methylethyl)-, ethyl ester

Synonyms:

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Chemical Property of 1H-Imidazole-5-carboxylic acid, 2-butyl-1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-4- (1-hydroxy-1-methylethyl)-, ethyl ester

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Technology Process of 1H-Imidazole-5-carboxylic acid, 2-butyl-1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-4- (1-hydroxy-1-methylethyl)-, ethyl ester

There total 5 articles about 1H-Imidazole-5-carboxylic acid, 2-butyl-1-[[2'-[(1,1-dimethylethoxy)carbonyl][1,1'-biphenyl]-4-yl]methyl]-4- (1-hydroxy-1-methylethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114772-40-6
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

: 144689-92-9
ethyl 2-butyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

: 144689-18-9
ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

Guidance literature:: With potassium tert-butylate; Yield given. Multistep reaction; 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h;
DOI:10.1021/jm950450f

Reference yield:

: 13820-09-2
trimethyl orthovalerate

: 144689-18-9
ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / 1.) CH₃CN, reflux, 5 h, 2.) xylene, reflux, 7 h

2: 69 percent / 6N aq. HCl / 8 h / Heating

3: 85 percent / HCl / Ambient temperature

4: 78 percent / diethyl ether; CH₂Cl₂ / 1 h / 10 - 15 °C

5: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

With hydrogenchloride; potassium tert-butylate; In diethyl ether; dichloromethane;
DOI:10.1021/jm950450f

Reference yield:

: 114772-25-7
2-butylimidazole-4,5-dicarbonitrile

: 144689-18-9
ethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / 6N aq. HCl / 8 h / Heating

2: 85 percent / HCl / Ambient temperature

3: 78 percent / diethyl ether; CH₂Cl₂ / 1 h / 10 - 15 °C

4: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

With hydrogenchloride; potassium tert-butylate; In diethyl ether; dichloromethane;
DOI:10.1021/jm950450f