[1,1'-Biphenyl]-2-carboxylic acid, 4'-[(6-imidazo[1,2-a]pyridin-2-yl-4-methyl-2-propyl-1H-benzimidazol-1-yl )methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:[1,1'-Biphenyl]-2-carboxylic acid, 4'-[(6-imidazo[1,2-a]pyridin-2-yl-4-methyl-2-propyl-1H-benzimidazol-1-yl )methyl]-, 1,1-dimethylethyl ester
CAS No.:144702-50-1
Molecular Formula:C36H36N4O2
Molecular Weight:556.707
Hs Code.:
Mol file:144702-50-1.mol

[1,1'-Biphenyl]-2-carboxylic acid,
4'-[(6-imidazo[1,2-a]pyridin-2-yl-4-methyl-2-propyl-1H-benzimidazol-1-yl
)methyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(6-imidazo[1,2-a]pyridin-2-yl-4-methyl-2-propyl-1H-benzimidazol-1-yl )methyl]-, 1,1-dimethylethyl ester

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Technology Process of [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(6-imidazo[1,2-a]pyridin-2-yl-4-methyl-2-propyl-1H-benzimidazol-1-yl )methyl]-, 1,1-dimethylethyl ester

There total 5 articles about [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(6-imidazo[1,2-a]pyridin-2-yl-4-methyl-2-propyl-1H-benzimidazol-1-yl )methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 504-29-0
2-aminopyridine

: 144702-50-1
tert.-butyl 4'-[[2-n-propyl-4-methyl-6-(imidazo[1,2-a]pyridin-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / ethanol / 2 h / Heating

2: N₂H₄*H₂O, Raney nickel / methanol / Heating

3: glacial CH₃COOH / 1.5 h / Heating

4: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h

With potassium tert-butylate; nickel; hydrazine hydrate; acetic acid; triethylamine; In methanol; ethanol;
DOI:10.1021/jm00077a007

Reference yield:

: 144703-00-4
4-(n-butyrylamino)-3-methyl-5-nitroacetophenone

: 144702-50-1
tert.-butyl 4'-[[2-n-propyl-4-methyl-6-(imidazo[1,2-a]pyridin-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂ / dioxane; diethyl ether / 0.25 h

2: Et₃N / ethanol / 2 h / Heating

3: N₂H₄*H₂O, Raney nickel / methanol / Heating

4: glacial CH₃COOH / 1.5 h / Heating

5: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h

With potassium tert-butylate; bromine; nickel; hydrazine hydrate; acetic acid; triethylamine; In 1,4-dioxane; methanol; diethyl ether; ethanol;
DOI:10.1021/jm00077a007

Reference yield:

: 144703-01-5
3-methyl-4-butyrylamino-5-nitro-ω-bromoacetophenone

: 144702-50-1
tert.-butyl 4'-[[2-n-propyl-4-methyl-6-(imidazo[1,2-a]pyridin-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / ethanol / 2 h / Heating

2: N₂H₄*H₂O, Raney nickel / methanol / Heating

3: glacial CH₃COOH / 1.5 h / Heating

4: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h

With potassium tert-butylate; nickel; hydrazine hydrate; acetic acid; triethylamine; In methanol; ethanol;
DOI:10.1021/jm00077a007