2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(3,4-dimethoxyphenyl)methyl]-4-hydroxy-7-oxo-, phenylmethyl ester, (1S,4S,5S)-

Base Information

Chemical Name:2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(3,4-dimethoxyphenyl)methyl]-4-hydroxy-7-oxo-, phenylmethyl ester, (1S,4S,5S)-
CAS No.:145574-13-6
Molecular Formula:C22H24N2O6
Molecular Weight:412.442
Hs Code.:
Mol file:145574-13-6.mol

Synonyms:

Suppliers and Price of 2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(3,4-dimethoxyphenyl)methyl]-4-hydroxy-7-oxo-, phenylmethyl ester, (1S,4S,5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(3,4-dimethoxyphenyl)methyl]-4-hydroxy-7-oxo-, phenylmethyl ester, (1S,4S,5S)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(3,4-dimethoxyphenyl)methyl]-4-hydroxy-7-oxo-, phenylmethyl ester, (1S,4S,5S)-

There total 3 articles about 2,6-Diazabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(3,4-dimethoxyphenyl)methyl]-4-hydroxy-7-oxo-, phenylmethyl ester, (1S,4S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 214837-07-7
(3S,4S)-<1-(3,4-dimethoxybenzyl)-2-oxo-4-<(R)-2-oxo-1,3-dioxololan-3-yl>azetidin-3-yl>carbamic acid benzyl ester

: 145574-13-6
benzyl (1S,4S,5S)-6-(3,4-dimethoxybenzyl)-4-hydroxy-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 140 ℃; for 5h;
DOI:10.1021/jm980023c

Reference yield:

: [(2S,3S)-2-((R)-1,2-Dihydroxy-ethyl)-1-(3,4-dimethoxy-benzyl)-4-oxo-azetidin-3-yl]-carbamic acid benzyl ester

: 145574-13-6
benzyl (1S,4S,5S)-6-(3,4-dimethoxybenzyl)-4-hydroxy-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / tetrahydrofuran / 4 h / Heating

2: 86 percent / Bu₄NBr / dimethylformamide / 5 h / 140 °C

With tetrabutylammomium bromide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm980023c