Benzenepropanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-5-(3-pyridinylmethyl)-, ethyl ester

Base Information

Chemical Name:Benzenepropanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-5-(3-pyridinylmethyl)-, ethyl ester
CAS No.:145691-89-0
Molecular Formula:C24H32N2O4
Molecular Weight:412.529
Hs Code.:
Mol file:145691-89-0.mol

Synonyms:

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Chemical Property of Benzenepropanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-5-(3-pyridinylmethyl)-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Benzenepropanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-5-(3-pyridinylmethyl)-, ethyl ester

There total 8 articles about Benzenepropanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-5-(3-pyridinylmethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-54-9,121697-66-3,1232169-17-3,68271-95-4
pyridine-3-carbonitrile

: 145691-89-0
ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(pyridin-3-ylmethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 30 min, 2.) ether, hexane, from -78 deg C to 0 deg C

2: 1.) N₂H₄*H₂O, ethylene glycol, 2.) KOH / 1.) reflux, 45 min, 2.) reflux, 30 min

3: 83 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

4: 95 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

5: 43 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: diphenyl phosphorazidate, Et₃N / 18 h / Heating

With palladium diacetate; potassium hydroxide; sodium hydroxide; n-butyllithium; diphenyl phosphoryl azide; ammonium formate; hydrazine hydrate; ethylene glycol; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 145691-89-0
ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(pyridin-3-ylmethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 30 min, 2.) ether, hexane, from -78 deg C to 0 deg C

2: 1.) N₂H₄*H₂O, ethylene glycol, 2.) KOH / 1.) reflux, 45 min, 2.) reflux, 30 min

3: 83 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

4: 95 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

5: 43 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: diphenyl phosphorazidate, Et₃N / 18 h / Heating

With palladium diacetate; potassium hydroxide; sodium hydroxide; n-butyllithium; diphenyl phosphoryl azide; ammonium formate; hydrazine hydrate; ethylene glycol; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 145691-54-9
3-(3,5-dibromobenzyl)pyridine

: 145691-89-0
ethyl 3-[3-(2-t-butoxycarbonylaminoethyl)-5-(pyridin-3-ylmethyl)phenyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / 1 h / Heating

2: 95 percent / HCO₂NH₄ / 10percent Pd/C / ethanol; tetrahydrofuran / 1 h / 60 °C

3: 43 percent / aq. NaOH / ethanol / 0.75 h / Heating

4: diphenyl phosphorazidate, Et₃N / 18 h / Heating

With palladium diacetate; sodium hydroxide; diphenyl phosphoryl azide; ammonium formate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile;