2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 936-12-9
• Molecular Formula: C8H11 N O2
• Molecular Weight: 153.181
• Hs Code.: 2933990090
• Mol file: 936-12-9.mol

Synonyms:Pyrrole-3-carboxylicacid, 2-methyl-, ethyl ester (6CI,7CI,8CI); 2-Methyl-1H-pyrrole-3-carboxylicacid ethyl ester; 3-(Ethoxycarbonyl)-2-methylpyrrole;3-Ethoxycarbonyl-2-methyl-1H-pyrrole; Ethyl 2-methylpyrrole-3-carboxylate; NSC81361

Chemical Property of 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00216mmHg at 25°C
• Melting Point: 78-79 °C(Solv: ethanol (64-17-5))
• Boiling Point: 289.7°Cat760mmHg
• PKA: 16.14±0.50(Predicted)
• Flash Point: 129°C
• PSA: 42.09000
• Density: 1.106g/cm³
• LogP: 1.49980
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-Methyl-1H-pyrrole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER

There total 25 articles about 2-METHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-Acetyl-2-methyl-1H-pyrrol-3-carbonsaeure-ethylester (74469-98-0) → 2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (936-12-9)

Guidance literature:

With sodium hydroxide; In methanol; for 0.25h;

Reference yield: 91.0%

2-acetyl-4-azido-3-methoxybutyric acid ethyl ester → 2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (936-12-9)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 80 ℃; for 4h;

DOI:10.1021/jo047856x

Reference yield: 86.0%

ethyl 1-methoxy-2-methyl-1H-pyrrole-3-carboxylate → 2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (936-12-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.1039/c6cc01742h

upstream raw materials:

Diazoethan

2-methyl-1H-pyrrole-3-carboxylic acid

vinyl acetate

glycine ethyl ester hydrochloride

Downstream raw materials:

ethyl 1-(4-fluorobenzyl)-2-methyl-1H-pyrrole-3-carboxylate

5-(3,5-di-tert-butylphenyl)-2-methyl-1-(piperidin-1-ylsulfonyl)-1H-pyrrole-3-carboxylic acid

ethyl 5-(3,5-di-tert-butylphenyl)-2-methyl-1-(piperidin-1-ylsulfonyl)-1H-pyrrole-3-carboxylate

ethyl 5-formyl-2-methyl-1H-pyrrole-3-carboxylate