[2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid benzyl ester
• CAS No.: 145881-74-9
• Molecular Formula: C12H17NO4
• Molecular Weight: 239.271
• European Community (EC) Number: 808-807-7
• Mol file: 145881-74-9.mol

Synonyms:145881-74-9;[2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid benzyl ester;Benzyl 2-(2-hydroxyethoxy)ethylcarbamate;Benzyl N-[2-(2-hydroxyethoxy)ethyl]carbamate;MFCD15143230;2-[2-(Cbz-amino)ethoxy]ethanol;CBZNH-PEG2-OH;SCHEMBL1699791;NFPGZLVPTVWFSY-UHFFFAOYSA-N;CBZ-NH-CH2CH2OCH2CH2-OH;Cbz-2-(2-hydroxyethoxy)ethanamine;AMY30976;CBZ-NH-CH2-CH2-OCH2CH2-OH;AKOS009220137;DS-10156;SY116020;CS-0062254;FT-0712009;EN300-137505;W17283;A884571;[2-(2-Hydroxy-ethoxy)-ethyl]-carbamicacidbenzylester;[2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid benzylester

Chemical Property of [2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid benzyl ester

Chemical Property:

• Boiling Point: 420.6±35.0 °C(Predicted)
• PKA: 11.99±0.46(Predicted)
• PSA: 67.79000
• Density: 1.170±0.06 g/cm3(Predicted)
• LogP: 1.31260
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 239.11575802
• Heavy Atom Count: 17
• Complexity: 205

Purity/Quality:

97% ^*data from raw suppliers

[2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid benzyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCCOCCO

Technology Process of [2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid benzyl ester

There total 4 articles about [2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl chloroformate (501-53-1,94274-21-2) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-<2-N-(benzyloxycarbonyl)aminoethoxy>ethanol (145881-74-9)

Guidance literature:

In 2-methyl-THF; at 10 - 20 ℃;

Reference yield: 95.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-<2-N-(benzyloxycarbonyl)aminoethoxy>ethanol (145881-74-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere; Cooling with ice;

Reference yield: 87.5%

→ 2-<2-N-(benzyloxycarbonyl)aminoethoxy>ethanol (145881-74-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

benzyl chloroformate

2-(2-Aminoethoxy)ethanol

N-(Benzyloxycarbonyloxy)succinimide

Downstream raw materials:

ethyl 2-<2-<2-N-(benzyloxycarbonyl)aminoethoxy>>-ethoxyethanesulfonate

C₁₈H₂₈ClNO₄

C₂₅H₂₇NO₄

2-(2-(((benzyloxy)carbonyl)amino)ethoxy)ethyl methanesulfonate