3-Fluorobicyclo[1.1.1]pentane-1-carboxylicacid

Base Information

• Chemical Name: 3-Fluorobicyclo[1.1.1]pentane-1-carboxylicacid
• CAS No.: 146038-53-1
• Molecular Formula: C6H7FO2
• Molecular Weight: 0.00000
• Hs Code.: 2916200090
• Mol file: 146038-53-1.mol

Synonyms:

Chemical Property of 3-Fluorobicyclo[1.1.1]pentane-1-carboxylicacid

Chemical Property:

• Melting Point: 117-118 °C
• Boiling Point: 217.0±40.0 °C(Predicted)
• PKA: 4.17±0.40(Predicted)
• PSA: 0.00000
• Density: 1.42±0.1 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

97% ^*data from raw suppliers

3-Fluorobicyclo[1.1.1]pentane-1-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Fluorobicyclo[1.1.1]pentane-1-carboxylicacid

There total 12 articles about 3-Fluorobicyclo[1.1.1]pentane-1-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

bicyclo<1.1.1>pentane-1,3-dicarboxylic acid (56842-95-6) → 3-fluorobicyclo<1.1.1>pentane-1-carboxylic acid (146038-53-1)

Guidance literature:

With silver nitrate; Selectfluor; In water; at 50 - 65 ℃; Inert atmosphere;

Reference yield: 65.0%

bicyclo<1.1.1>pentane-1,3-dicarboxylic acid (56842-95-6) → 3-fluorobicyclo<1.1.1>pentane-1-carboxylic acid (146038-53-1)

Guidance literature:

With silver nitrate; Selectfluor; In water; at 65 ℃; for 16h; Temperature; Inert atmosphere;

DOI:10.1039/c5ob02066b

Reference yield: 38.0%

1-fluoro-3-phenylbicyclo<1.1.1>pentane + acetonitrile (75-05-8,26809-02-9) → 3-fluorobicyclo<1.1.1>pentane-1-carboxylic acid (146038-53-1)

Guidance literature:

With sodium periodate; ruthenium(III) chloride trihydrate; In dichloromethane; water; at 20 ℃;

upstream raw materials:

1-bromo-3-(4,4-dimethyl-2-oxazolinyl)bicyclo<1.1.1>pentane

1-iodo-3-phenylbicyclo<1.1.1>pentane

3-bromobicyclo<1.1.1>pentane-1-carboxylic acid

3-Bromo-bicyclo[1.1.1]pentane-1-carbonyl chloride