5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine

Base Information

Chemical Name:5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine
CAS No.:146062-57-9
Molecular Formula:C10H15NO2
Molecular Weight:181.23200
Hs Code.:
DSSTox Substance ID:DTXSID301258689

Synonyms:146062-57-9;5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine;5-[1-(methoxymethoxy)ethyl]-2-methylpyridine;5-(1-methoxymethoxyethyl)-2-methylpyridine;starbld0002401;SCHEMBL7836592;AOHSDRCYABCFTI-UHFFFAOYSA-N;DTXSID301258689;5-(1-methoxymethoxy-ethyl)-2-methyl-pyridine

Suppliers and Price of 5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine
500mg
$ 1320.00

Medical Isotopes, Inc.
5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine
500 mg
$ 2200.00

Total 5 raw suppliers

Chemical Property of 5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine

Chemical Property:

Boiling Point:237.5±30.0 °C(Predicted)
PSA：31.35000
Density:1.016±0.06 g/cm3(Predicted)
LogP:2.07150
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:181.110278721
Heavy Atom Count:13
Complexity:141

Purity/Quality:

99% ^*data from raw suppliers

5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC=C(C=C1)C(C)OCOC
Uses 5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine is a reactant used in the synthesis of the metabolites of Pioglitazone (P471000), an antidiabetic, anihyperglycemic agent.

Technology Process of 5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine

There total 4 articles about 5-(1-(Methoxymethoxy)ethyl)-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 56019-64-8,100189-16-0,110338-86-8
5-(1-hydroxyethyl)-2-methylpyridine

: 107-30-2
chloromethyl methyl ether

: 146062-57-9
3-(1-(methoxymethoxy)ethyl)-6-methylpyridine

Guidance literature:: 5-(1-hydroxyethyl)-2-methylpyridine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

chloromethyl methyl ether; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 36357-38-7
1-(6-methyl-pyridin-3-yl)-ethanone

: 146062-57-9
3-(1-(methoxymethoxy)ethyl)-6-methylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NaBH₄ / ethanol / 1.5 h / 0 °C

2: 1.) NaH / 1.) hexane, DMF, 0 deg C, 1.5 h, 2.) hexane, DMF, from -78 deg C to RT

With sodium tetrahydroborate; sodium hydride; In ethanol;
DOI:10.1021/jm9605694

Reference yield:

: 5470-70-2
Methyl 6-methylnicotinate

: 146062-57-9
3-(1-(methoxymethoxy)ethyl)-6-methylpyridine

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide; toluene / 2.5 h / 80 °C

2: 10percent aq. H₂SO₄ / 2 h / Heating

3: 90 percent / NaBH₄ / ethanol / 1.5 h / 0 °C

4: 1.) NaH / 1.) hexane, DMF, 0 deg C, 1.5 h, 2.) hexane, DMF, from -78 deg C to RT

With sodium tetrahydroborate; sulfuric acid; sodium hydride; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm9605694