Benzenemethanol, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-

Base Information

• Chemical Name: Benzenemethanol, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-
• CAS No.: 146952-73-0
• Molecular Formula: C24H28O2Si
• Molecular Weight: 376.571
• DSSTox Substance ID: DTXSID50453229
• Nikkaji Number: J2.112.021I
• Wikidata: Q82274326
• Mol file: 146952-73-0.mol

Synonyms:146952-73-0;(4-(((tert-Butyldiphenylsilyl)oxy)methyl)phenyl)methanol;Benzenemethanol, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-;[4-[[tert-butyl(diphenyl)silyl]oxymethyl]phenyl]methanol;(4-((tert-butyldiphenylsilyloxy)methyl)phenyl)methanol;(4-{[(TERT-BUTYLDIPHENYLSILYL)OXY]METHYL}PHENYL)METHANOL;C24H28O2Si;SCHEMBL2745018;DTXSID50453229;WFA95273;MFCD21362363;AM804736;AS-72224;CS-0036905;W10509;4-(tert-Butyldiphenylsiloxymethyl)benzyl alcohol;A1-30649;(-4Tert-Butyldiphenylsilyl)Oxy)Methyl)Phenyl)Methanol

Chemical Property of Benzenemethanol, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-

Chemical Property:

• PSA: 29.46000
• LogP: 4.25550
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 376.185856666
• Heavy Atom Count: 27
• Complexity: 406

Purity/Quality:

97% ^*data from raw suppliers

[4-[[tert-butyl(diphenyl)silyl]oxymethyl]phenyl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OCC3=CC=C(C=C3)CO

Technology Process of Benzenemethanol, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-

There total 4 articles about Benzenemethanol, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-[(tert-butyldimethylsilyloxy)methyl]-1-[(tert-butyldiphenylsilyloxy)methyl]benzene (146952-72-9) → [4-({[tert-butyl(diphenyl)silyl]oxy}methyl)phenyl]methanol (146952-73-0)

Guidance literature:

With sodium tetrachloroaurate(III) dihydrate; In methanol; at 20 ℃; for 7h;

DOI:10.1055/s-0034-1379032

Reference yield: 95.0%

C33H48O2Si2 → [4-({[tert-butyl(diphenyl)silyl]oxy}methyl)phenyl]methanol (146952-73-0)

Guidance literature:

With hafnium tetrakis(trifluoromethanesulfonate); In methanol; at 20 ℃; for 5h; chemoselective reaction;

DOI:10.1055/s-0037-1610307

Reference yield: 87.0%

p-xylylene glycol (589-29-7) + tert-butylchlorodiphenylsilane (58479-61-1) → [4-({[tert-butyl(diphenyl)silyl]oxy}methyl)phenyl]methanol (146952-73-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 24h;

DOI:10.1021/ol016915f

upstream raw materials:

p-xylylene glycol

tert-butylchlorodiphenylsilane

methyl 4-({[tert-butyl(diphenyl)silyl]oxy}methyl)benzoate

4-[(tert-butyldimethylsilyloxy)methyl]-1-[(tert-butyldiphenylsilyloxy)methyl]benzene

Downstream raw materials:

tert-butyldiphenyl-(4-iodomethylbenzyloxy)-silane

(4-{(1R,2S,3R)-1,3-Bis-[4-((1S,2S,3R)-1,3-dimethoxy-2-methoxymethyl-butyl)-benzyloxy]-2-[4-((1S,2S,3R)-1,3-dimethoxy-2-methoxymethyl-butyl)-benzyloxymethyl]-butyl}-benzyloxy)-tert-butyl-diphenyl-silane

(4-{(1R,2S,3R)-1,3-Bis-[4-((1R,2S,3R)-1,3-dimethoxy-2-methoxymethyl-butyl)-benzyloxy]-2-[4-((1R,2S,3R)-1,3-dimethoxy-2-methoxymethyl-butyl)-benzyloxymethyl]-butyl}-benzyloxy)-tert-butyl-diphenyl-silane

C₅₇H₈₃BrO₁₂