Thieno[3,4-d]pyrimidine, 4-chloro-5,7-dihydro-2-methyl-

Base Information

Chemical Name:Thieno[3,4-d]pyrimidine, 4-chloro-5,7-dihydro-2-methyl-
CAS No.:5719-46-0
Molecular Formula:C7H7 Cl N2 S
Molecular Weight:186.665
Hs Code.:
European Community (EC) Number:227-222-2
UNII:FK57N775CT
DSSTox Substance ID:DTXSID6063989
Nikkaji Number:J225.115I
Wikidata:Q72518496
Mol file:5719-46-0.mol

Synonyms:5719-46-0;4-chloro-2-methyl-5,7-dihydrothieno[3,4-d]pyrimidine;Thieno[3,4-d]pyrimidine, 4-chloro-5,7-dihydro-2-methyl-;EINECS 227-222-2;4-Chloro-5,7-dihydro-2-methylthieno(3,4-d)pyrimidine;4-Chloro-5,7-dihydro-2-methylthieno[3,4-d]pyrimidine;FK57N775CT;Thieno(3,4-d)pyrimidine, 4-chloro, 5,7-dihydro-2-methyl;Thieno(3,4-d)pyrimidine, 4-chloro-5,7-dihydro-2-methyl-;4-CHLORO-2-METHYL-5,7-DIHYDROTHIENO(3,4-D)PYRIMIDINE;UNII-FK57N775CT;DTXSID6063989;AKOS017975492

Suppliers and Price of Thieno[3,4-d]pyrimidine, 4-chloro-5,7-dihydro-2-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of Thieno[3,4-d]pyrimidine, 4-chloro-5,7-dihydro-2-methyl-

Chemical Property:

Vapor Pressure:0.00047mmHg at 25°C
Melting Point:70-72℃
Boiling Point:324.3°Cat760mmHg
Flash Point:149.9°C
PSA：51.08000
Density:1.406g/cm³
LogP:2.18520
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:186.0018471
Heavy Atom Count:11
Complexity:155

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=C(CSC2)C(=N1)Cl

Technology Process of Thieno[3,4-d]pyrimidine, 4-chloro-5,7-dihydro-2-methyl-

There total 2 articles about Thieno[3,4-d]pyrimidine, 4-chloro-5,7-dihydro-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 5719-23-3
2-methyl-3H-5,7-dihydrothieno<3,4-d>pyrimidin-4-one

: 5719-46-0
4-chloro-2-methyl-5,7-dihydrothieno<3,4-d>pyrimidine

Guidance literature:: With triethylamine; trichlorophosphate; for 1.5h; Heating;
DOI:10.1016/0040-4020(95)01009-2

Reference yield:

: 5719-46-0
4-chloro-2-methyl-5,7-dihydrothieno<3,4-d>pyrimidine

Guidance literature:: Methylamidin, /BRN= 957115/;

Reference yield:

: 5719-46-0
4-chloro-2-methyl-5,7-dihydrothieno<3,4-d>pyrimidine

: 2-methyl-7-phenyl-5,5a,8a,9-tetrahydropyrrolo<3,4-g>quinazolin-6,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / mCPBA / CH₂Cl₂ / 18 h / Ambient temperature

2: 92 percent / H₂, AcOK / 10percent Pd/C / toluene / 760 Torr / Ambient temperature

3: 75 percent / various solvent(s) / 3 h / Heating

With hydrogen; potassium acetate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane; toluene;
DOI:10.1016/0040-4020(95)01009-2