5-Chloro-3,4-dihydroquinoxalin-2(1H)-one

Base Information

Chemical Name:5-Chloro-3,4-dihydroquinoxalin-2(1H)-one
CAS No.:148010-70-2
Molecular Formula:C8H7ClN2O
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID20441693
Wikidata:Q82258575
Mol file:148010-70-2.mol

Synonyms:5-Chloro-3,4-dihydroquinoxalin-2(1H)-one;148010-70-2;5-chloro-3,4-dihydro-1H-quinoxalin-2-one;5-chloro-1,2,3,4-tetrahydroquinoxalin-2-one;2(1H)-Quinoxalinone, 5-chloro-3,4-dihydro-;SCHEMBL1346523;DTXSID20441693;MZCZOGGMZQMPTI-UHFFFAOYSA-N;AKOS016000934;EN300-3015876;A911324

Suppliers and Price of 5-Chloro-3,4-dihydroquinoxalin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 5-Chloro-3,4-dihydroquinoxalin-2(1H)-one

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:182.0246905
Heavy Atom Count:12
Complexity:198

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC2=C(N1)C(=CC=C2)Cl

Technology Process of 5-Chloro-3,4-dihydroquinoxalin-2(1H)-one

There total 1 articles about 5-Chloro-3,4-dihydroquinoxalin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148858-03-1
4-tert-butyl-5-chloro-1,2,3,4-tetrahydroquinoxalin-2-one

: 55687-19-9
5-chloroquinoxaline-2(1H)-one

: 148010-70-2
5-chloro-1,2,3,4-tetrahydroquinoxalin-2-one

Guidance literature:: With sulfuric acid; for 18h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jm940765f

Reference yield:

: 148010-70-2
5-chloro-3,4-dihydro-quinoxalin-2-ol

: 2-[4-(5-chloro-quinoxalin-2-yloxy)-phenoxy]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 3percent aq. H₂O₂; aq. NaOH / 1 h / Heating

2: 69 percent / K₂CO₃ / acetonitrile / 6 h / Heating

3: 96 percent / aq. O_.1 N NaOH / tetrahydrofuran

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm0005149

Reference yield:

: 148010-70-2
5-chloro-3,4-dihydro-quinoxalin-2-ol

: 347162-27-0
2-[4-(5-chloro-quinoxalin-2-yloxy)-phenoxy]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 3percent aq. H₂O₂; aq. NaOH / 1 h / Heating

2: 69 percent / K₂CO₃ / acetonitrile / 6 h / Heating

With sodium hydroxide; potassium carbonate; In acetonitrile;
DOI:10.1021/jm0005149