1,1,2,2-Tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)ethanesulfonamide

Base Information

• Chemical Name: 1,1,2,2-Tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)ethanesulfonamide
• CAS No.: 148716-83-0
• Molecular Formula: C4H2F8INO3S
• Molecular Weight: 423.023
• DSSTox Substance ID: DTXSID80576137
• Nikkaji Number: J607.919I
• Wikidata: Q82465685
• Mol file: 148716-83-0.mol

Synonyms:148716-83-0;1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)ethanesulfonamide;1,1,2,2-TETRAFLUORO-2-(1,1,2,2-TETRAFLUORO-2-IODOETHOXY)-ETHANESULFONAMIDE;1,1,2,2-Tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)ethane-1-sulfonamide;DTXSID80576137

Chemical Property of 1,1,2,2-Tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)ethanesulfonamide

Chemical Property:

• Boiling Point: 269.8±50.0 °C(Predicted)
• PKA: 7.10±0.60(Predicted)
• Density: 2.247±0.06 g/cm3(Predicted)
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 5
• Exact Mass: 422.86724
• Heavy Atom Count: 18
• Complexity: 417

Purity/Quality:

1,1,2,2-TETRAFLUORO-2-(1,1,2,2-TETRAFLUORO-2-IODOETHOXY)ETHANESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(F)(F)S(=O)(=O)N)(OC(C(F)(F)I)(F)F)(F)F

Technology Process of 1,1,2,2-Tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)ethanesulfonamide

There total 14 articles about 1,1,2,2-Tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

para-xylene (106-42-3) + 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl azide (144951-87-1) → N-(5'-iodo-3'-oxa-octafluoropentyl)-sulfonyl-2,5-dimethylaniline + 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl amide (148716-83-0)

Guidance literature:

at 120 ℃; for 48h;

DOI:10.1016/j.tet.2005.03.094

Reference yield: 33.0%

1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl azide (144951-87-1) + 1,4-dimethoxybezene (150-78-7) → N-(5'-iodo-3'-oxa-octafluoropentyl)-sulfonyl-2,5-dimethoxylaniline + 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl amide (148716-83-0)

Guidance literature:

at 120 ℃; for 48h;

DOI:10.1016/j.tet.2005.03.094

Reference yield: 28.0%

1-methyl-4-nitrobenzene (99-99-0) + 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl azide (144951-87-1) → 1,1,2,2-tetrafluoro-N-(2-methyl-5-nitrophenyl)-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)ethanesulfonamide (1314878-78-8) + 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl amide (148716-83-0)

Guidance literature:

at 120 ℃; for 32h; Inert atmosphere; Neat (no solvent);

DOI:10.1016/j.tet.2011.05.027

upstream raw materials:

styrene

N,N-Dichloro-5-iodo-3-oxa-octafluoropentane sulfonyl amide

styrene oxide

ICF₂CF₂OCF₂CF₂SO₂N=S=O

Downstream raw materials:

1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoroethoxy)-ethanesulfonyl amide