5,6-difluoro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Base Information

Chemical Name:5,6-difluoro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
CAS No.:214287-72-6
Molecular Formula:C₁₄H₁₁F₅N₂O
Molecular Weight:318.246
Hs Code.:
Mol file:214287-72-6.mol

Synonyms:2(1H)-Quinazolinone,5,6-difluoro-3,4-dihydro-4-(3-methyl-1-butynyl)-4-(trifluoromethyl)- (9CI)

Suppliers and Price of 5,6-difluoro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,6-difluoro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Chemical Property:

Vapor Pressure:0.00024mmHg at 25°C
Boiling Point:324.8°Cat760mmHg
Flash Point:150.2°C
Density:1.42g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5,6-difluoro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

There total 5 articles about 5,6-difluoro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 65108-24-9
1-lithio-3-methyl-1-butyne

: 214288-05-8
5,6-difluoro-4-trifluoromethylquinazolin-2(1H)-one

: 214287-72-6,214287-92-0
5,6-difluoro-3,4-dihydro-4-(3-methylbutyn-1-yl)-4-(trifluoromethyl)-2(1H)-quinazolinone

Guidance literature:: With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jm990580e

Reference yield:

: 205756-47-4
o-aminotrifluoromethyl ketone

: 214287-72-6,214287-92-0
5,6-difluoro-3,4-dihydro-4-(3-methylbutyn-1-yl)-4-(trifluoromethyl)-2(1H)-quinazolinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran

1.2: tetrabutylammonium fluoride / tetrahydrofuran

2.1: xylene / Heating

3.1: boron trifluoride diethyl etherate / tetrahydrofuran

With boron trifluoride diethyl etherate; In tetrahydrofuran; xylene;
DOI:10.1128/aac.43.12.2893

Reference yield:

: 214288-04-7
5,6-difluoro-3,4-dihydro-4-hydroxy-4-trifluoromethylquinazolin-2(1H)-one

: 214287-72-6,214287-92-0
5,6-difluoro-3,4-dihydro-4-(3-methylbutyn-1-yl)-4-(trifluoromethyl)-2(1H)-quinazolinone

Guidance literature:: Multi-step reaction with 2 steps

1: xylene / Heating

2: boron trifluoride diethyl etherate / tetrahydrofuran

With boron trifluoride diethyl etherate; In tetrahydrofuran; xylene;
DOI:10.1128/aac.43.12.2893