2-(1H-Imidazol-1-yl)-1-(4-methylphenyl)ethan-1-one

Base Information

• Chemical Name: 2-(1H-Imidazol-1-yl)-1-(4-methylphenyl)ethan-1-one
• CAS No.: 24155-37-1
• Molecular Formula: C12H12 N2 O
• Molecular Weight: 200.24
• DSSTox Substance ID: DTXSID10555617
• Nikkaji Number: J565.874H
• Wikidata: Q82437014
• Mol file: 24155-37-1.mol

Synonyms:24155-37-1;2-(1H-Imidazol-1-yl)-1-(4-methylphenyl)ethan-1-one;SCHEMBL10247597;DTXSID10555617

Chemical Property of 2-(1H-Imidazol-1-yl)-1-(4-methylphenyl)ethan-1-one

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 200.094963011
• Heavy Atom Count: 15
• Complexity: 222

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)CN2C=CN=C2

Technology Process of 2-(1H-Imidazol-1-yl)-1-(4-methylphenyl)ethan-1-one

There total 6 articles about 2-(1H-Imidazol-1-yl)-1-(4-methylphenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1H-imidazole (288-32-4) + 4-(bromoacetyl)toluene (619-41-0) → 1-(4-methylphenyl)-2-(1H-imidazol-1-yl)ethan-1-one (24155-37-1)

Guidance literature:

With lithium hydride; In tetrahydrofuran; at -5 - 0 ℃; for 3h;

DOI:10.3987/COM-06-10726

Reference yield: 86.0%

1H-imidazole (288-32-4) + para-methylacetophenone (122-00-9) → 1-(4-methylphenyl)-2-(1H-imidazol-1-yl)ethan-1-one (24155-37-1)

Guidance literature:

With sodium iodide dichloride; In ethanol; water; for 2h; Reflux;

DOI:10.1002/jhet.4412

Reference yield: 75.0%

1H-imidazole (288-32-4) + 4-(bromoacetyl)toluene (619-41-0) → 1-(4-methylphenyl)-2-(1H-imidazol-1-yl)ethan-1-one (24155-37-1) + 1-(2-Oxo-2-m-tolyl-ethyl)-3-(2-oxo-2-p-tolyl-ethyl)-3H-imidazol-1-ium; bromide

Guidance literature:

In N,N-dimethyl-formamide; at 5 - 10 ℃; for 3h;

DOI:10.1016/0223-5234(93)90110-Z

upstream raw materials:

1H-imidazole

4-(bromoacetyl)toluene

para-methylacetophenone

Downstream raw materials:

N-<2-(1H-imidazol-1-yl)-1-(4-methylphenyl)ethylidene>methanamine N-oxide

1-(4-methylphenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

1-(4-methylphenyl)-2-(1H-imidazol-1-yl) ethanone, 2,4-dinitrophenylhydrazone, hydrochloride

1,3-bis(4-methylphenyl)-2-(1H-imidazol-1-yl)-prop-2-en-1-one