2-Butenoic acid, 2-cyano-3-(4-fluorophenyl)-, ethyl ester

Base Information

Chemical Name:2-Butenoic acid, 2-cyano-3-(4-fluorophenyl)-, ethyl ester
CAS No.:15297-64-0
Molecular Formula:C13H12FNO2
Molecular Weight:233.242
Hs Code.:
Mol file:15297-64-0.mol

Synonyms:Ethyl-α-cyano-p-fluoro-β-methylcinnamide;2-cyano-3-(4-fluoro-phenyl)-but-2-enoic acid ethyl ester;2-BUTENOIC ACID, 2-CYANO-3-(4-FLUOROPHENYL)-, ETHYL ESTER;

Suppliers and Price of 2-Butenoic acid, 2-cyano-3-(4-fluorophenyl)-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-Butenoic acid, 2-cyano-3-(4-fluorophenyl)-, ethyl ester

Chemical Property:

PSA：50.09000
LogP:2.68588

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Butenoic acid, 2-cyano-3-(4-fluorophenyl)-, ethyl ester

There total 3 articles about 2-Butenoic acid, 2-cyano-3-(4-fluorophenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 403-42-9
1-(4-fluorophenyl)ethanone

: 105-56-6
ethyl 2-cyanoacetate

: 15297-64-0
ethyl 2-cyano-3-(4-fluorophenyl)-2-butenoate

Guidance literature:: With ammonium acetate; acetic acid; In toluene; Heating;
DOI:10.1021/jm990957g

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 105-56-6
ethyl 2-cyanoacetate

: 15297-64-0,54441-05-3
C₁₃H₁₂FNO₂

: 54441-05-3
(Z)-2-Cyano-3-(4-fluoro-phenyl)-but-2-enoic acid ethyl ester

Guidance literature:: With ammonium acetate; acetic acid; In toluene; for 22h; Overall yield = 62 %; Reflux; Dean-Stark;
DOI:10.1002/anie.201810470