1,3-Benzenedicarboxamide, 5-[[2-(acetyloxy)-5-chloro-1-oxopentyl]amino]-N,N'-bis[2,3-bis(acetyloxy )propyl]-2,4,6-triiodo-

Base Information

• Chemical Name: 1,3-Benzenedicarboxamide, 5-[[2-(acetyloxy)-5-chloro-1-oxopentyl]amino]-N,N'-bis[2,3-bis(acetyloxy )propyl]-2,4,6-triiodo-
• CAS No.: 153714-14-8
• Molecular Formula: C29H35ClI3N3O13
• Molecular Weight: 1049.78
• Mol file: 153714-14-8.mol

Synonyms:

Chemical Property of 1,3-Benzenedicarboxamide, 5-[[2-(acetyloxy)-5-chloro-1-oxopentyl]amino]-N,N'-bis[2,3-bis(acetyloxy )propyl]-2,4,6-triiodo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Benzenedicarboxamide, 5-[[2-(acetyloxy)-5-chloro-1-oxopentyl]amino]-N,N'-bis[2,3-bis(acetyloxy )propyl]-2,4,6-triiodo-

There total 6 articles about 1,3-Benzenedicarboxamide, 5-[[2-(acetyloxy)-5-chloro-1-oxopentyl]amino]-N,N'-bis[2,3-bis(acetyloxy )propyl]-2,4,6-triiodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-amino-N,N'-bis[2,3-bis(acetyloxy)propyl]2,4,6-triiodo-1,3-benzenedicarboxamide (76801-94-0) + 2-Acetoxy-5-chloropentanoyl chloride (153714-13-7) → Acetic acid 2-[3-(2-acetoxy-5-chloro-pentanoylamino)-5-(2,3-diacetoxy-propylcarbamoyl)-2,4,6-triiodo-benzoylamino]-1-acetoxymethyl-ethyl ester (153714-14-8)

Guidance literature:

In N,N-dimethyl acetamide; for 15h; Ambient temperature;

DOI:10.1016/0040-4020(96)00668-0

Reference yield:

tetrahydrofuran-2-carbonyl chloride (52449-98-6) → Acetic acid 2-[3-(2-acetoxy-5-chloro-pentanoylamino)-5-(2,3-diacetoxy-propylcarbamoyl)-2,4,6-triiodo-benzoylamino]-1-acetoxymethyl-ethyl ester (153714-14-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / pyridine / diethyl ether / 0.67 h / 0 °C

2: 85 percent / ZnCl₂ / 17 h / Heating

3: 87 percent / H₂, acetic acid / 5percent Pd/C / ethyl acetate / 1 h / 517.1 Torr

4: 97 percent / oxalyl chloride / 15 h / 25 °C

5: 79 percent / N,N-dimethyl-acetamide / 15 h / Ambient temperature

With pyridine; oxalyl dichloride; hydrogen; acetic acid; zinc(II) chloride; palladium on activated charcoal; In diethyl ether; N,N-dimethyl acetamide; ethyl acetate;

DOI:10.1016/0040-4020(96)00668-0

Reference yield:

tetrahydro-2-furancarboxylic acid (16874-33-2) → Acetic acid 2-[3-(2-acetoxy-5-chloro-pentanoylamino)-5-(2,3-diacetoxy-propylcarbamoyl)-2,4,6-triiodo-benzoylamino]-1-acetoxymethyl-ethyl ester (153714-14-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / oxalyl chloride / 15 h / Ambient temperature

2: 100 percent / pyridine / diethyl ether / 0.67 h / 0 °C

3: 85 percent / ZnCl₂ / 17 h / Heating

4: 87 percent / H₂, acetic acid / 5percent Pd/C / ethyl acetate / 1 h / 517.1 Torr

5: 97 percent / oxalyl chloride / 15 h / 25 °C

6: 79 percent / N,N-dimethyl-acetamide / 15 h / Ambient temperature

With pyridine; oxalyl dichloride; hydrogen; acetic acid; zinc(II) chloride; palladium on activated charcoal; In diethyl ether; N,N-dimethyl acetamide; ethyl acetate;

DOI:10.1016/0040-4020(96)00668-0

upstream raw materials:

5-amino-N,N'-bis[2,3-bis(acetyloxy)propyl]2,4,6-triiodo-1,3-benzenedicarboxamide

2-Acetoxy-5-chloropentanoyl chloride

tetrahydrofuran-2-carbonyl chloride

tetrahydro-2-furancarboxylic acid

Downstream raw materials:

5-[3-(Acetyloxy)-2-oxo-1-piperidinyl]N,N'-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-1,3-benzenedicarboxamide