Technology Process of Veliflapon
There total 6 articles about Veliflapon which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; sodium phosphate;
In
acetonitrile;
at 35 ℃;
for 40h;
pH=6.7;
DOI:10.1021/ja0680109
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: t-BuOK / diethyl ether / 0.5 h / 0 °C
1.2: diethyl ether / 0 - 20 °C
2.1: aq. HClO4 / diethyl ether / 20 °C
3.1: 91 percent / K2CO3 / dimethylformamide / 5 h / Heating
4.1: H2; t-BuOK / RuCl2[(S)-DMM-SDP](R,R)-DACH / propan-2-ol / 8 h / 20 °C / 375030 Torr
5.1: 89 percent / TEMPO; aq. Na3PO4; NaClO2 / acetonitrile / 40 h / 35 °C / pH 6.7
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; perchloric acid; potassium tert-butylate; hydrogen; potassium carbonate; sodium phosphate;
RuCl2[(S)-DMM-SDP](R,R)-DACH;
In
diethyl ether; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
1.2: Wittig reaction;
DOI:10.1021/ja0680109
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. HClO4 / diethyl ether / 20 °C
2: 91 percent / K2CO3 / dimethylformamide / 5 h / Heating
3: H2; t-BuOK / RuCl2[(S)-DMM-SDP](R,R)-DACH / propan-2-ol / 8 h / 20 °C / 375030 Torr
4: 89 percent / TEMPO; aq. Na3PO4; NaClO2 / acetonitrile / 40 h / 35 °C / pH 6.7
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; perchloric acid; potassium tert-butylate; hydrogen; potassium carbonate; sodium phosphate;
RuCl2[(S)-DMM-SDP](R,R)-DACH;
In
diethyl ether; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/ja0680109
